Background Among patients with non–small-cell lung cancer (NSCLC), data on intratumor
heterogeneity and cancer genome evolution have been limited to small retrospective cohorts. …

The early detection of relapse following primary surgery for non-small-cell lung cancer and
the characterization of emerging subclones, which seed metastatic sites, might offer new …

Immune evasion is a hallmark of cancer. Losing the ability to present neoantigens through
human leukocyte antigen (HLA) loss may facilitate immune evasion. However, the …

With the use of a mouse model expressing human Fc-gamma receptors (FcγRs), we
demonstrated that antibodies with isotypes equivalent to ipilimumab and tremelimumab mediate …

CD25 is expressed at high levels on regulatory T (Treg) cells and was initially proposed as
a target for cancer immunotherapy. However, anti-CD25 antibodies have displayed limited …

The importance of intratumour genetic and functional heterogeneity is increasingly recognised
as a driver of cancer progression and survival outcome. Understanding how tumour …

BACKGROUND: Although pediatric cancer mortality and survival have improved in the
United States over the past 40 years, differences exist by age, race/...

Highlights•AGN effectively prevents ROT-induced motor deficits and striatal dopaminergic
neuronal loss.•AGN inhibits ROT induced α-synuclein accumulation in Substantia …

The first outbreak of Candida haemulonii fungemia is described. The seven isolates from
the blood of four neonates were identified by DNA sequencing of the ribosomal DNA. They …

Background High mammographic density is a therapeutically modifiable risk factor for
breast cancer. Although mammographic density is correlated with the relative abundance of …