Calorie restriction extends lifespan and produces a metabolic profile desirable for treating
diseases of ageing such as type 2 diabetes 1 , 2 . SIRT1, an NAD + -dependent deacetylase, …

Antithrombin, a plasma serpin, is relatively inactive as an inhibitor of the coagulation
proteases until it binds to the heparan side chains that line the microvasculature. The binding …

In this article, we characterize the fluorescence of an environmentally sensitive probe for
lipid membranes, di-4-ANEPPDHQ. In large unilamellar lipid vesicles (LUVs), its emission …

Owing to the exceptional properties of graphene, intensive studies have been carried out on
novel two-dimensional (2D) materials. In the past several years, an elegant exfoliation …

Mislocated enzymatic activity of DOT1L has been proposed as a driver of leukemogenesis
in mixed lineage leukemia (MLL). The characterization of EPZ004777, a potent, selective …

BACKGROUND & AIMS: Recent studies have suggested that CD4 + CD25 + regulatory T
cells (Treg) are increased and linked to compromised immune responses in patients with …

EZH2 catalyzes trimethylation of histone H3 lysine 27 (H3K27). Point mutations of EZH2 at
Tyr641 and Ala677 occur in subpopulations of non-Hodgkin's lymphoma, where they drive …

CD4+ CD25+ regulatory T cells (Treg) have been shown to maintain immune tolerance
against self and foreign Ags, but their role in persistent viral infection has not been well-defined. …

Rearrangements of the MLL gene define a genetically distinct subset of acute leukemias
with poor prognosis. Current treatment options are of limited effectiveness; thus, there is a …

Interleukin‐17 (IL‐17)‐producing CD4 + T cells (Th17)‐mediated immune response has been
demonstrated to play a critical role in inflammation‐associated disease; however, its role …