User profiles for Leidy D. Caraballo
 | Leidy Diana Caraballo GalvaPostdoctoral Associate at Texas Children's Hospital-Baylor College of Medicine Verified email at bcm.edu Cited by 377 |
Large-scale design of robust genetic circuits with multiple inputs and outputs for mammalian cells
BH Weinberg, NTH Pham, LD Caraballo… - Nature …, 2017 - nature.com
Engineered genetic circuits for mammalian cells often require extensive fine-tuning to perform
as intended. We present a robust, general, scalable system, called 'Boolean logic and …
as intended. We present a robust, general, scalable system, called 'Boolean logic and …
[HTML][HTML] High-performance chemical-and light-inducible recombinases in mammalian cells and mice
Site-specific DNA recombinases are important genome engineering tools. Chemical- and
light-inducible recombinases, in particular, enable spatiotemporal control of gene expression. …
light-inducible recombinases, in particular, enable spatiotemporal control of gene expression. …
Inducible gene switches with memory in human T cells for cellular immunotherapy
D Chakravarti, LD Caraballo, BH Weinberg… - ACS synthetic …, 2019 - ACS Publications
Cell-based therapies that employ engineered T cells—including those modified to express
chimeric antigen receptors (CARs)—to target cancer cells have demonstrated promising …
chimeric antigen receptors (CARs)—to target cancer cells have demonstrated promising …
[HTML][HTML] Preclinical Studies of the Off-Target Reactivity of AFP158-Specific TCR Engineered T Cells
Autologous T cells engineered with T receptor genes (TCR) are being studied to treat
cancers. We have recently identified a panel of mouse TCRs specific for the HLA-A0201/alpha …
cancers. We have recently identified a panel of mouse TCRs specific for the HLA-A0201/alpha …
[HTML][HTML] A single-layer platform for boolean logic and arithmetic through dna excision in mammalian cells
BH Weinberg, NTH Pham, LD Caraballo… - Nature …, 2017 - ncbi.nlm.nih.gov
Genetic circuits engineered for mammalian cells often require extensive fine-tuning to
perform their intended functions. To overcome this problem, we present a generalizable …
perform their intended functions. To overcome this problem, we present a generalizable …
Novel low-avidity glypican-3 specific CARTs resist exhaustion and mediate durable antitumor effects against hepatocellular carcinoma
Chimeric antigen receptor engineered T cells (CARTs) are being developed to treat solid
tumors including hepatocellular carcinoma (HCC). However, thus far, CARTs have not been as …
tumors including hepatocellular carcinoma (HCC). However, thus far, CARTs have not been as …
Abstract B62: Development of novel chimeric antigen receptor T cells for immunotherapy of hepatocellular carcinoma
X Jiang, LD Caraballo G, H Zhang, X Chi, Y Peng… - Cancer Immunology …, 2020 - AACR
Background and Aim: Several glypican 3 (hGPC3)-specific chimeric-antigen-receptor modified
T cells (CARTs) are in trials for hepatocellular carcinoma (HCC), but most are constructed …
T cells (CARTs) are in trials for hepatocellular carcinoma (HCC), but most are constructed …
Novel low-avidity glypican-3 specific CARTs resist exhaustion and mediate durable antitumor effects against hepatocellular carcinoma
Methods and results New human glypican-3 (hGPC3) mAbs were developed from immunized
mice. We obtained 3 hGPC3-specific mAbs that stained HCC tumors, but not the adjacent …
mice. We obtained 3 hGPC3-specific mAbs that stained HCC tumors, but not the adjacent …
Preclinical studies of the off-target reactivity of AFP158-specific TCR engineered T cells
Y He, L Cai, LD Caraballo-Galva… - The Journal of …, 2020 - journals.aai.org
Autologous T cells engineered with T receptor genes (TCR-T) are being studied to treat
cancers. We have recently identified a panel of mouse TCRs specific for the HLA-A0201/alpha …
cancers. We have recently identified a panel of mouse TCRs specific for the HLA-A0201/alpha …
Novel low‐avidity glypican‐3 specific CARTs resist exhaustion and mediate durable antitumor effects against HCC
Methods and Results New human glypican‐3 (hGPC3) mAbs were developed from immunized
mice. We obtained three hGPC3‐specific mAbs that stained HCC tumors, but not the …
mice. We obtained three hGPC3‐specific mAbs that stained HCC tumors, but not the …