Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs …
…, AG Loxton, G van der Spuy, K Stanley, LA Kotzé… - Thorax, 2016 - thorax.bmj.com
Background User-friendly, rapid, inexpensive yet accurate TB diagnostic tools are urgently
needed at points of care in resource-limited settings. We investigated host biomarkers …
needed at points of care in resource-limited settings. We investigated host biomarkers …
Safety and immunogenicity of VPM1002 versus BCG in South African newborn babies: a randomised, phase 2 non-inferiority double-blind controlled trial
…, S Bhikha, G Walzl, A Gutschmidt, LA Kotze… - The Lancet Infectious …, 2022 - thelancet.com
Background Tuberculosis is a major public health problem worldwide. Immunisation with
Mycobacterium bovis BCG vaccine is partially effective in infants, reducing the incidence of …
Mycobacterium bovis BCG vaccine is partially effective in infants, reducing the incidence of …
[HTML][HTML] Therapies for tuberculosis and AIDS: myeloid-derived suppressor cells in focus
A Dorhoi, LA Kotzé, JA Berzofsky, Y Sui… - The Journal of …, 2020 - Am Soc Clin Investig
The critical role of suppressive myeloid cells in immune regulation has come to the forefront
in cancer research, with myeloid-derived suppressor cells (MDSCs) as a main oncology …
in cancer research, with myeloid-derived suppressor cells (MDSCs) as a main oncology …
Establishment of a patient-derived, magnetic levitation-based, three-dimensional spheroid granuloma model for human tuberculosis
Tuberculous granulomas that develop in response to Mycobacterium tuberculosis ( M.
tuberculosis ) infection are highly dynamic entities shaped by the host immune response and …
tuberculosis ) infection are highly dynamic entities shaped by the host immune response and …
[HTML][HTML] Caveolin-1 controls vesicular TLR2 expression, p38 signaling and T cell suppression in BCG infected murine monocytic myeloid-derived suppressor cells
Monocytic myeloid-derived suppressor cells (M-MDSCs) and granulocytic MDSCs (G-MDSCs)
have been found to be massively induced in TB patients as well in murine Mtb infection …
have been found to be massively induced in TB patients as well in murine Mtb infection …
[HTML][HTML] Mycobacterium tuberculosis and myeloid-derived suppressor cells: Insights into caveolin rich lipid rafts
Mycobacterium tuberculosis (M.tb) is likely the most successful human pathogen, capable of
evading protective host immune responses and driving metabolic changes to support its …
evading protective host immune responses and driving metabolic changes to support its …
[HTML][HTML] Translational potential of therapeutics targeting regulatory myeloid cells in tuberculosis
N Du Plessis, LA Kotze, V Leukes… - Frontiers in Cellular and …, 2018 - frontiersin.org
Despite recent advances in tuberculosis (TB) drug development and availability, successful
antibiotic treatment is challenged by the parallel development of antimicrobial resistance. As …
antibiotic treatment is challenged by the parallel development of antimicrobial resistance. As …
Evaluation of autophagy mediators in myeloid-derived suppressor cells during human tuberculosis
Myeloid-derived suppressor cells (MDSC) are induced during active TB disease to restore
immune homeostasis but instead exacerbate disease outcome due to chronic inflammation. …
immune homeostasis but instead exacerbate disease outcome due to chronic inflammation. …
[HTML][HTML] Targeted gene expression profiling of human myeloid cells from blood and lung compartments of patients with tuberculosis and other lung diseases
LA Kotze, G van der Spuy, B Leonard… - Frontiers in …, 2022 - frontiersin.org
Myeloid-derived suppressor cells (MDSC) have been identified in the peripheral blood and
granulomas of patients with active TB disease, but their phenotype-, function-, and …
granulomas of patients with active TB disease, but their phenotype-, function-, and …
[HTML][HTML] Immunometabolism of Myeloid-Derived Suppressor Cells: Implications for Mycobacterium tuberculosis Infection and Insights from Tumor Biology
The field of immunometabolism seeks to decipher the complex interplay between the
immune system and the associated metabolic pathways. The role of small molecules that can …
immune system and the associated metabolic pathways. The role of small molecules that can …