User profiles for Lekhika Pathak

Lekhika Pathak

PhD student, KaviKrishna Laboratory, IIT-Guwahati
Verified email at iitg.ac.in
Cited by 68

[HTML][HTML] Coronavirus activates an altruistic stem cell–mediated defense mechanism that reactivates dormant tuberculosis: implications in coronavirus disease 2019 …

L Pathak, S Gayan, B Pal, J Talukdar, S Bhuyan… - The American journal of …, 2021 - Elsevier
We postulate that similar to bacteria, adult stem cells may also exhibit an altruistic defense
mechanism to protect their niche against external threat. Herein, we report mesenchymal stem …

[HTML][HTML] The emerging role of oral microbiota in oral cancer initiation, progression and stemness

PJ Saikia, L Pathak, S Mitra, B Das - Frontiers in Immunology, 2023 - frontiersin.org
Oral squamous cell carcinoma (OSCC) is the most prevalent malignancy among the Head
and Neck cancer. OSCCs are highly inflammatory, immune-suppressive, and aggressive …

[HTML][HTML] Initiation of post-primary tuberculosis of the lungs: Exploring the secret role of bone marrow derived stem cells

L Pathak, B Das - Frontiers in immunology, 2021 - frontiersin.org
Mycobacterium tuberculosis (Mtb), the causative organism of pulmonary tuberculosis (PTB)
now infects more than half of the world population. The efficient transmission strategy of the …

[HTML][HTML] Targeting hypoxia-induced tumor stemness by activating pathogen-induced stem cell niche defense

S Bhuyan, B Pal, L Pathak, PJ Saikia, S Mitra… - Frontiers in …, 2022 - frontiersin.org
Tumor hypoxia and oxidative stress reprograms cancer stem cells (CSCs) to a highly
aggressive and inflammatory phenotypic state of tumor stemness. Previously, we characterized …

Corona virus activates a stem cell mediated defense mechanism that accelerates activation of dormant tuberculosis: implications for the COVID-19 pandemic

L Pathak, S Gayan, B Pal, J Talukdar, S Bhuyan… - bioRxiv, 2020 - biorxiv.org
We postulate that similar to bacteria, adult stem cells may also exhibit altruistic defense
mechanism to protect their niche. Here, we provide preliminary data on the altruistic stem cell (…

Circulating tumor cells exhibit a tumor stemness defense phenotype in Head and Neck cancer

L Pathak, B Pal, DJ Talukdar, PJ Saikia… - Frontiers in …, 2023 - frontiersin.org
Circulating tumor cells (CTCs) are under extensive research for their significance in
diagnosing cancer metastasis or post-therapy recurrence. CTC may also predict response to …

A novel comprehensive Tuberculosis (TB) control programme methodology based on the nexus of participatory action research inspired public health and precision …

…, G Das, T Baishya, C Das, T Sarma, S Das, L Pathak… - medRxiv, 2024 - medrxiv.org
Tuberculosis is emerging as a major global health issue for the under-developed regions
across the world including India's North East. Importantly, the incidence of multidrug-resistant (…

Stem cell basis of a host driven transmission of antigen packed aerosols: a novel mechanism of natural vaccination for tuberculosis

B Das, L Pathak, S Gayan, B Pal, P Saikia, T Baishya… - bioRxiv, 2020 - biorxiv.org
Natural vaccination against pathogens are known to be achieved by herd-immunity ie
infected human host provide immunity to the community by spreading the pathogen. Whether, …

[HTML][HTML] 90 Circulating altruistic stem cells as a marker of immunosuppression in oral cancer

L Pathak, S Bhuyan, B Pal, P Saikia, S Gayan, S Mitra… - 2022 - jitc.bmj.com
Background Head & neck cancer is the 4th cancer, and most of them are diagnosed late, and
treated with cisplatin monotherapy. In these subsets of patients, immunotherapy has been …

Fusobacterium Nucleatum and HPV16 cooperate to reprogram the human primary oral keratinocyte to enhanced stemness state, a newly identified pre-malignant cell …

I Akeel, B Pal, PJ Saikia, L Pathak, S Sorra, B Das - Cancer Research, 2020 - AACR
The mechanism of HPV16 induced malignant transformation of oral epithelial cells is not yet
clear. We speculated that HPV16 may induce stem cell altruism that reprogram specific …