User profiles for Len W. Seymour
Len Seymouruniversity of oxford Verified email at oncology.ox.ac.uk Cited by 6631 |
Conjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vivo
1. INTRODUCTION There is a pressing need for thedevelopment of more effective and yet
less toxic drugs for thetreatment of diseases such as cancer and AIDS. The use of …
less toxic drugs for thetreatment of diseases such as cancer and AIDS. The use of …
Phase II studies of polymer-doxorubicin (PK1, FCE28068) in the treatment of breast, lung and colorectal cancer
Phase I studies of [N-(2-hydroxypropyl)methacrylamide] (HPMA) copolymer-doxorubicin
previously showed signs of activity coupled with 5-fold decreased anthracycline toxicity in …
previously showed signs of activity coupled with 5-fold decreased anthracycline toxicity in …
Key issues in non-viral gene delivery
CW Pouton, LW Seymour - Advanced drug delivery reviews, 2001 - Elsevier
The future of non-viral gene therapy depends on a detailed understanding of the barriers to
delivery of polynucleotides. These include physicomechanical barriers, which limit the …
delivery of polynucleotides. These include physicomechanical barriers, which limit the …
[PDF][PDF] Hepatic drug targeting: phase I evaluation of polymer-bound doxorubicin
LW Seymour, DR Ferry, D Anderson… - Journal of clinical …, 2002 - Citeseer
Purpose: Preclinical studies have shown good anti-cancer activity following targeting of a
polymer bearing doxorubicin with galactosamine (PK2) to the liver. The present phase I study …
polymer bearing doxorubicin with galactosamine (PK2) to the liver. The present phase I study …
An oncolytic virus expressing a T-cell engager simultaneously targets cancer and immunosuppressive stromal cells
…, A Lambert, P Miller, BR Champion, LW Seymour… - Cancer research, 2018 - AACR
An engineered oncolytic adenovirus that encodes a bispecific antibody combines direct
virolysis with endogenous T-cell activation to attack stromal fibroblasts, providing a multimodal …
virolysis with endogenous T-cell activation to attack stromal fibroblasts, providing a multimodal …
[HTML][HTML] Use of tissue-specific microRNA to control pathology of wild-type adenovirus without attenuation of its ability to kill cancer cells
…, N van Rooijen, LW Seymour - PLoS …, 2009 - journals.plos.org
Replicating viruses have broad applications in biomedicine, notably in cancer virotherapy and
in the design of attenuated vaccines; however, uncontrolled virus replication in vulnerable …
in the design of attenuated vaccines; however, uncontrolled virus replication in vulnerable …
Peptide-mediated RNA delivery: a novel approach for enhanced transfection of primary and post-mitotic cells
Synthetic vectors were evaluated for their ability to mediate efficient mRNA transfection. Initial
results indicated that lipoplexes, but not polyplexes based on polyethylenimine (PEI, 25 …
results indicated that lipoplexes, but not polyplexes based on polyethylenimine (PEI, 25 …
In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity
…, T Etrych, KD Fisher, LW Seymour… - Nature …, 2015 - nature.com
The efficacy of vaccine adjuvants such as Toll-like receptor agonists (TLRa) can be improved
through formulation and delivery approaches. Here, we attached small molecule TLR-7/8a …
through formulation and delivery approaches. Here, we attached small molecule TLR-7/8a …
A versatile reducible polycation-based system for efficient delivery of a broad range of nucleic acids
Synthetic vectors based on reducible polycations consisting of histidine and polylysine
residues (HIS RPCs) were evaluated for their ability to deliver nucleic acids. Initial experiments …
residues (HIS RPCs) were evaluated for their ability to deliver nucleic acids. Initial experiments …
Characterization of vectors for gene therapy formed by self-assembly of DNA with synthetic block co-polymers
…, K Ulbrich, O Nazarova, LW Seymour - Human gene …, 1996 - liebertpub.com
Cationic polymers can self-assemble with DNA to form polyelectrolyte complexes capable
of gene delivery, although biocompatibility of the complexes is generally limited. Here we …
of gene delivery, although biocompatibility of the complexes is generally limited. Here we …