User profiles for Lena Amend

Lena Amend

- Verified email at helmholtz-hiri.de - Cited by 582

Anna-Lena Amend

- Verified email at pharmalex.com - Cited by 23

[HTML][HTML] Modulation of inflammatory responses by gastrointestinal Prevotella spp.–from associations to functional studies

A Iljazovic, L Amend, EJC Galvez, R de Oliveira… - International Journal of …, 2021 - Elsevier
Numerous studies have associated alterations in the gut microbiota composition with almost
every known inflammatory disease. However, proving the biological relevance of distinct …

[HTML][HTML] Perturbation of the gut microbiome by Prevotella spp. enhances host susceptibility to mucosal inflammation

…, TR Lesker, B Zhao, A Gronow, L Amend… - Mucosal …, 2021 - Elsevier
Diverse microbial signatures within the intestinal microbiota have been associated with
intestinal and systemic inflammatory diseases, but whether these candidate microbes actively …

[PDF][PDF] Distinct polysaccharide utilization determines interspecies competition between intestinal Prevotella spp.

EJC Gálvez, A Iljazovic, L Amend, TR Lesker… - Cell Host & Microbe, 2020 - cell.com
Prevotella spp. are a dominant bacterial genus within the human gut. Multiple Prevotella spp.
co-exist in some individuals, particularly those consuming plant-based diets. Additionally, …

[HTML][HTML] Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer

…, M Peschka, F Cortesi, K Riecken, M Jung, L Amend… - Nature, 2023 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is expected to be the second most deadly
cancer by 2040, owing to the high incidence of metastatic disease and limited responses to …

[PDF][PDF] Extension of the Segatella copri complex to 13 species with distinct large extrachromosomal elements and associations with host conditions

…, EJC Gálvez, E Pasolli, F De Filippis, L Amend… - Cell Host & Microbe, 2023 - cell.com
The Segatella copri (formerly Prevotella copri) complex (ScC) comprises taxa that are key
members of the human gut microbiome. It was previously described to contain four distinct …

[HTML][HTML] Characterization of serum biomarkers and antibody responses against Prevotella spp. in preclinical and new-onset phase of rheumatic diseases

L Amend, BTP Gilbert, P Pelczar, M Böttcher… - Frontiers in Cellular …, 2023 - frontiersin.org
Introduction The characterization of the influence of the microbiota on the development and
drug responses during rheumatic diseases has intensified in recent years. The role of …

A versatile genetic toolbox for Prevotella copri enables studying polysaccharide utilization systems

J Li, EJC Gálvez, L Amend, É Almási, A Iljazovic… - The EMBO …, 2021 - embopress.org
Prevotella copri is a prevalent inhabitant of the human gut and has been associated with
plant‐rich diet consumption and diverse health states. The underlying genetic basis of these …

[HTML][HTML] Brief report: Assessment of mucosal barrier integrity using serological biomarkers in preclinical stages of rheumatoid arthritis

BTP Gilbert, C Lamacchia, L Amend, T Strowig… - Frontiers in …, 2023 - frontiersin.org
Background The pathogenesis of rheumatoid arthritis (RA) is believed to initiate at mucosal
sites. The so-called ‘mucosal origin hypothesis of RA’ postulates an increased intestinal …

[HTML][HTML] Distinct Microbial Taxa Are Associated with LDL-Cholesterol Reduction after 12 Weeks of Lactobacillus plantarum Intake in Mild Hypercholesterolemia …

F Kerlikowsky, M Müller, T Greupner, L Amend… - Probiotics and …, 2023 - Springer
Probiotic microbes such as Lactobacillus may reduce serum total cholesterol (TC) and low-density
lipoprotein (LDL) cholesterol. The objective of this study was to assess the effect of …

[HTML][HTML] A point mutation in the Pdia6 gene results in loss of pancreatic β-cell identity causing overt diabetes

NF Chhabra, AL Amend, A Bastidas-Ponce… - Molecular …, 2021 - Elsevier
Objective Protein disulfide isomerases (PDIs) are oxidoreductases that are involved in
catalyzing the formation and rearrangement of disulfide bonds during protein folding. One of the …