[PDF][PDF] A reference human induced pluripotent stem cell line for large-scale collaborative studies
Human induced pluripotent stem cell (iPSC) lines are a powerful tool for studying
development and disease, but the considerable phenotypic variation between lines makes it …
development and disease, but the considerable phenotypic variation between lines makes it …
Regulation of Zbp1 by miR-99b-5p in microglia controls the development of schizophrenia-like symptoms in mice
…, S Burkhardt, AL Schuetz, T Pena, L Erlebach… - The EMBO …, 2024 - embopress.org
Current approaches to the treatment of schizophrenia have mainly focused on the protein-coding
part of the genome; in this context, the roles of microRNAs have received less attention. …
part of the genome; in this context, the roles of microRNAs have received less attention. …
A novel miR-99b-5p-Zbp1 pathway in microglia contributes to the pathogenesis of schizophrenia
Schizophrenia is a psychiatric disorder that is still not readily treatable. Pharmaceutical
advances in the treatment of schizophrenia have mainly focused on the protein coding part of the …
advances in the treatment of schizophrenia have mainly focused on the protein coding part of the …
Multi‐omic profiling of isogenic ApoE3/3 and ApoE4/4 iPSC‐derived astrocytes uncovers altered lipid metabolism and mitochondrial function of ApoE4 astrocytes
…, ID Kruijff, D Olivier‐Jimenez, L Erlebach… - Alzheimer's & …, 2023 - Wiley Online Library
Background As the main genetic risk factor for AD, glial ApoE4 has been implicated in a
number of early disease relevant processes, such as lipid dyshomeostasis, mitochondrial …
number of early disease relevant processes, such as lipid dyshomeostasis, mitochondrial …
Multiomics of iPSC‐derived ApoE3‐and ApoE4 astrocytes and microglia uncovers cell type specific dysregulation of immunometabolism
R van der Kant, N Blomberg, L Erlebach… - Alzheimer's & …, 2023 - Wiley Online Library
Background ApoE4 is the major genetic risk factor for Alzheimer’s disease and the main
lipid transporter in brain. How ApoE4 drives AD pathogenesis, and how this is related to …
lipid transporter in brain. How ApoE4 drives AD pathogenesis, and how this is related to …
New in vitro tools to investigate the role of microglia in neurodegeneration
L Erlebach, M Welzer, A Bühler, D Miely… - Alzheimer's & …, 2023 - Wiley Online Library
Background Human induced pluripotent stem cells (iPSCs) have transpired as an attractive
tool to investigate neurological diseases. And while immune cells, and in particular microglia…
tool to investigate neurological diseases. And while immune cells, and in particular microglia…
Understanding the protective effect of the PLCG2 P522R variant in human microglia
J Frik, A Robert, S Koppes, L Erlebach… - Alzheimer's & …, 2023 - Wiley Online Library
Background Although recent advances in the field suggest significant involvement of the
shared pathway between the proteins ApoE and TREM2 in the pathogenesis of late onset …
shared pathway between the proteins ApoE and TREM2 in the pathogenesis of late onset …
Stroke after transcatheter aortic valve replacement: a severe complication with low predictability
LK Eschenbach, M Erlebach… - Catheterization and …, 2022 - Wiley Online Library
Objectives We aimed to describe stroke and transient ischemic attacks (TIAs) after transcatheter
aortic valve replacement (TAVR) and to identify associated risk factors. Background …
aortic valve replacement (TAVR) and to identify associated risk factors. Background …
Surgical explantation of a dehiscent cardioband
…, A Prinzing, U Herold, M Erlebach… - JACC: Cardiovascular …, 2019 - jacc.org
California) is a new mitral valve transcatheter annuloplasty device implanted transseptally on
the beating heart under fluoroscopic and transesophageal echocardiographic visualization …
the beating heart under fluoroscopic and transesophageal echocardiographic visualization …