Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster

…, D Kühnert, KI Bos, LR Davis, L Mikalová… - Nature …, 2016 - nature.com
The abrupt onslaught of the syphilis pandemic that started in the late fifteenth century
established this devastating infectious disease as one of the most feared in human history 1. …

[HTML][HTML] Whole Genome Sequence of Treponema pallidum ssp. pallidum, Strain Mexico A, Suggests Recombination between Yaws and Syphilis Strains

H Pětrošová, M Zobaníková, D Čejková, L Mikalová… - 2012 - journals.plos.org
Background Treponema pallidum ssp. pallidum (TPA), the causative agent of syphilis, and
Treponema pallidum ssp. pertenue (TPE), the causative agent of yaws, are closely related …

Molecular typing of Treponema pallidum in the Czech Republic during 2011 to 2013: increased prevalence of identified genotypes and of isolates with macrolide …

L Grillová, H Pĕtrošová, L Mikalová… - Journal of clinical …, 2014 - Am Soc Microbiol
From January 2011 to December 2013, a total of 262 samples, from 188 patients suspected
of having syphilis were tested for the presence of treponemal DNA by PCR amplification of …

[HTML][HTML] Resequencing of Treponema pallidum ssp. pallidum Strains Nichols and SS14: Correction of Sequencing Errors Resulted in Increased Separation of …

…, M Strouhal, D Čejková, M Zobaníková, L Mikalová… - PloS one, 2013 - journals.plos.org
Background Treponema pallidum ssp. pallidum (TPA), the causative agent of syphilis, is a
highly clonal bacterium showing minimal genetic variability in the genome sequence of …

[HTML][HTML] Genome Analysis of Treponema pallidum subsp. pallidum and subsp. pertenue Strains: Most of the Genetic Differences Are Localized in Six Regions

L Mikalová, M Strouhal, D Čejková, M Zobaníková… - PloS one, 2010 - journals.plos.org
The genomes of eight treponemes including T. p. pallidum strains (Nichols, SS14, DAL-1
and Mexico A), T. p. pertenue strains (Samoa D, CDC-2 and Gauthier), and the Fribourg-Blanc …

[HTML][HTML] Bacteriocin-encoding genes and ExPEC virulence determinants are associated in human fecal Escherichia coli strains

L Micenková, B Štaudová, J Bosák, L Mikalová… - BMC microbiology, 2014 - Springer
Background A set of 1181 E. coli strains of human fecal origin isolated in the South Moravia
region of the Czech Republic was collected during the years 2007–2010. Altogether, 17 …

[PDF][PDF] Sequencing-based molecular typing of Treponema pallidum strains in the Czech Republic: all identified genotypes are related to the sequence of the SS14 …

…, P Pospíšilová, L Mikalová… - Acta dermato …, 2012 - medicaljournalssweden.se
A set of 415 clinical samples isolated from 294 patients suspected of having syphilis collected
in the Czech Republic between 2004 and 2010 was tested for the presence of treponemal …

[HTML][HTML] Whole Genome Sequence of the Treponema Fribourg-Blanc: Unspecified Simian Isolate Is Highly Similar to the Yaws Subspecies

M Zobaníková, M Strouhal, L Mikalová… - PLoS neglected …, 2013 - journals.plos.org
Background Unclassified simian strain Treponema Fribourg-Blanc was isolated in 1966
from baboons (Papio cynocephalus) in West Africa. This strain was morphologically …

Nonhuman primates across sub-Saharan Africa are infected with the yaws bacterium Treponema pallidum subsp. pertenue

…, A Düx, M Strouhal, L Mikalová… - Emerging microbes & …, 2018 - Taylor & Francis
Although syphilis has reached a worldwide distribution 2, bejel and yaws have remained
endemic diseases. Bejel affects individuals in dry areas of Sahelian Africa and Saudi Arabia, …

[HTML][HTML] Directly sequenced genomes of contemporary strains of syphilis reveal recombination-driven diversity in genes encoding predicted surface-exposed antigens

L Grillová, J Oppelt, L Mikalová, M Nováková… - Frontiers in …, 2019 - frontiersin.org
Syphilis, caused by Treponema pallidum subsp. pallidum (TPA), remains an important public
health problem with an increasing worldwide prevalence. Despite recent advances in in …