Hutchinson–Gilford progeria syndrome (HGPS) is a rare and fatal human premature ageing
disease 1 , 2 , 3 , 4 , 5 , characterized by premature arteriosclerosis and degeneration of …

Background— Long noncoding RNAs (lncRNAs) have emerged as critical epigenetic
regulators with important functions in development and disease. Here, we sought to identify and …

Long non-coding RNAs (lncRNAs) can act as scaffolds that promote the interaction of
proteins, RNA, and DNA. There is increasing evidence of sequence-specific interactions of …

Trait-associated loci often map to genomic regions encoding long noncoding RNAs (lncRNAs),
but the role of these lncRNAs in disease etiology is largely unexplored. We show that a …

Heart failure is a leading cause of mortality and morbidity in the developed world, partly
because mammals lack the ability to regenerate heart tissue. Whether this is due to evolutionary …

Lineage conversion of one somatic cell type to another is an attractive approach for
generating specific human cell types. Lineage conversion can be direct, in the absence of …

The blueprints of developing organs are preset at the early stages of embryogenesis.
Transcriptional and epigenetic mechanisms are proposed to preset developmental trajectories. …

Polyamines are essential organic polycations with multiple cellular functions relevant for cell
division, cancer and ageing 1 , 2 , 3 . Regulation of polyamine synthesis is mainly achieved …

10.7554/eLife.08833.001 Longevity mechanisms increase lifespan by counteracting the
effects of aging. However, whether longevity mechanisms counteract the effects of aging …

While the transcriptional network of human embryonic stem cells (hESCs) has been extensively
studied, relatively little is known about how post-transcriptional modulations determine …