User profiles for Leo Speidel

Leo Speidel

UCL and Francis Crick Institute
Verified email at ucl.ac.uk
Cited by 1006

A method for genome-wide genealogy estimation for thousands of samples

L Speidel, M Forest, S Shi, SR Myers - Nature genetics, 2019 - nature.com
Abstract Knowledge of genome-wide genealogies for thousands of individuals would
simplify most evolutionary analyses for humans and other species, but has remained …

Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

…, LE Petty, H Kitajima, GZ Yu, S Rüeger, L Speidel… - Nature …, 2022 - nature.com
We assembled an ancestrally diverse collection of genome-wide association studies (GWAS)
of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non…

[PDF][PDF] Disentangling selection on genetically correlated polygenic traits via whole-genome genealogies

AJ Stern, L Speidel, NA Zaitlen, R Nielsen - The American Journal of …, 2021 - cell.com
We present a full-likelihood method to infer polygenic adaptation from DNA sequence variation
and GWAS summary statistics to quantify recent transient directional selection acting on …

[HTML][HTML] Grey wolf genomic history reveals a dual ancestry of dogs

…, L Girdland-Flink, DM Fernandes, M Ollivier, L Speidel… - Nature, 2022 - nature.com
The grey wolf (Canis lupus) was the first species to give rise to a domestic population, and
they remained widespread throughout the last Ice Age when many other large mammal …

Inferring population histories for ancient genomes using genome-wide genealogies

L Speidel, L Cassidy, RW Davies… - Molecular Biology …, 2021 - academic.oup.com
Ancient genomes anchor genealogies in directly observed historical genetic variation and
contextualize ancestral lineages with archaeological insights into their geography and cultural …

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

…, LE Petty, H Kitajima, GZ Yu, S Rüeger, L Speidel… - MedRxiv, 2020 - medrxiv.org
We assembled an ancestrally diverse collection of genome-wide association studies of type
2 diabetes (T2D) in 180,834 cases and 1,159,055 controls (48.9% non-European descent). …

[HTML][HTML] The selection landscape and genetic legacy of ancient Eurasians

…, T Vimala, H McColl, AH Vaughn, L Speidel… - Nature, 2024 - nature.com
The Holocene (beginning around 12,000 years ago) encompassed some of the most significant
changes in human evolution, with far-reaching consequences for the dietary, physical …

[HTML][HTML] Detection of chromosomal aneuploidy in ancient genomes

K Anastasiadou, M Silva, T Booth, L Speidel… - Communications …, 2024 - nature.com
Ancient DNA is a valuable tool for investigating genetic and evolutionary history that can
also provide detailed profiles of the lives of ancient individuals. In this study, we develop a …

Balancing selection on genomic deletion polymorphisms in humans

A Aqil, L Speidel, P Pavlidis, O Gokcumen - Elife, 2023 - elifesciences.org
A key question in biology is why genomic variation persists in a population for extended
periods. Recent studies have identified examples of genomic deletions that have remained …

Topological data analysis of continuum percolation with disks

L Speidel, HA Harrington, SJ Chapman, MA Porter - Physical Review E, 2018 - APS
We study continuum percolation with disks, a variant of continuum percolation in two-dimensional
Euclidean space, by applying tools from topological data analysis. We interpret each …