User profiles for Leo Speidel
Leo SpeidelUCL and Francis Crick Institute Verified email at ucl.ac.uk Cited by 1006 |
A method for genome-wide genealogy estimation for thousands of samples
Abstract Knowledge of genome-wide genealogies for thousands of individuals would
simplify most evolutionary analyses for humans and other species, but has remained …
simplify most evolutionary analyses for humans and other species, but has remained …
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
We assembled an ancestrally diverse collection of genome-wide association studies (GWAS)
of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non…
of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non…
[PDF][PDF] Disentangling selection on genetically correlated polygenic traits via whole-genome genealogies
We present a full-likelihood method to infer polygenic adaptation from DNA sequence variation
and GWAS summary statistics to quantify recent transient directional selection acting on …
and GWAS summary statistics to quantify recent transient directional selection acting on …
[HTML][HTML] Grey wolf genomic history reveals a dual ancestry of dogs
The grey wolf (Canis lupus) was the first species to give rise to a domestic population, and
they remained widespread throughout the last Ice Age when many other large mammal …
they remained widespread throughout the last Ice Age when many other large mammal …
Inferring population histories for ancient genomes using genome-wide genealogies
Ancient genomes anchor genealogies in directly observed historical genetic variation and
contextualize ancestral lineages with archaeological insights into their geography and cultural …
contextualize ancestral lineages with archaeological insights into their geography and cultural …
Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
We assembled an ancestrally diverse collection of genome-wide association studies of type
2 diabetes (T2D) in 180,834 cases and 1,159,055 controls (48.9% non-European descent). …
2 diabetes (T2D) in 180,834 cases and 1,159,055 controls (48.9% non-European descent). …
[HTML][HTML] The selection landscape and genetic legacy of ancient Eurasians
The Holocene (beginning around 12,000 years ago) encompassed some of the most significant
changes in human evolution, with far-reaching consequences for the dietary, physical …
changes in human evolution, with far-reaching consequences for the dietary, physical …
[HTML][HTML] Detection of chromosomal aneuploidy in ancient genomes
Ancient DNA is a valuable tool for investigating genetic and evolutionary history that can
also provide detailed profiles of the lives of ancient individuals. In this study, we develop a …
also provide detailed profiles of the lives of ancient individuals. In this study, we develop a …
Balancing selection on genomic deletion polymorphisms in humans
A key question in biology is why genomic variation persists in a population for extended
periods. Recent studies have identified examples of genomic deletions that have remained …
periods. Recent studies have identified examples of genomic deletions that have remained …
Topological data analysis of continuum percolation with disks
We study continuum percolation with disks, a variant of continuum percolation in two-dimensional
Euclidean space, by applying tools from topological data analysis. We interpret each …
Euclidean space, by applying tools from topological data analysis. We interpret each …