Blood cells play essential roles in human health, underpinning physiological processes
such as immunity, oxygen transport, and clotting, which when perturbed cause a significant …

Most loci identified by GWASs have been found in populations of European ancestry (EUR).
In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including …

Aims While most patients with myocardial infarction (MI) have underlying coronary atherosclerosis,
not all patients with coronary artery disease (CAD) develop MI. We sought to address …

Coronary artery disease (CAD) is the commonest cause of death. Here, we report an
association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching …

Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in
epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery …

Nuclear magnetic resonance assays allow for measurement of a wide range of metabolic
phenotypes. We report here the results of a GWAS on 8,330 Finnish individuals genotyped and …

Genome-wide association studies have identified numerous loci linked with complex diseases,
for which the molecular mechanisms remain largely unclear. Comprehensive molecular …

OBJECTIVE: MicroRNAs are small non-coding RNAs that inversely regulate their target
gene expression. The whole miRNA profile of human atherosclerotic plaques has not been …

General cognitive function is a prominent and relatively stable human trait that is associated
with many important life outcomes. We combine cognitive and genetic data from the …

Atrial fibrillation (AF) affects more than 33 million individuals worldwide 1 and has a complex
heritability 2 . We conducted the largest meta-analysis of genome-wide association studies (…