TRANSCRIPTIONAL activation of target genes represents an important component of the
tumour-suppressor function of p53 and provides a functional link between p53 and various …

The nuclear functions of NF-κB p50/RelA heterodimers are regulated in part by posttranslational
modifications of its RelA subunit, including phosphorylation and acetylation. Acetylation …

Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion
of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide …

Exposure of mammalian cells to hypoxia, radiation and certain chemotherapeutic agents
promotes cell cycle arrest and/or apoptosis. Activation of p53 responsive genes is believed to …

Bone is accrued and maintained primarily through the coupled actions of bone-forming
osteoblasts and bone-resorbing osteoclasts. Cumulative in vitro studies indicated that proline-…

Objective Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome.
We aimed to derive HFpEF phenotype-based groups ('phenogroups') based on clinical …

Proline-rich tyrosine kinase 2 (PYK2) is a cytoplasmic, non-receptor tyrosine kinase implicated
in multiple signaling pathways. It is a negative regulator of osteogenesis and considered …

PF-1355 is an oral myeloperoxidase (MPO) inhibitor that successfully decreased elevated
MPO activity in mouse myocardial infarction models. Short duration PF-1355 treatment for 7 …

Signalling pathways that control endothelial cell (EC) permeability, leukocyte adhesion and
inflammation are pivotal for atherosclerosis initiation and progression. Here we demonstrate …

This work addresses the link between selectivity and an unusual, folded conformation for
the P-loop observed initially for MAP4K4 and subsequently for other kinases. Statistical and …