User profiles for Leonard Hartmanis
 | Leonard HartmanisPhD in single-cell genomics Verified email at ki.se Cited by 1036 |
[HTML][HTML] Transcriptional kinetics and molecular functions of long noncoding RNAs
An increasing number of long noncoding RNAs (lncRNAs) have experimentally confirmed
functions, yet little is known about their transcriptional dynamics and it is challenging to …
functions, yet little is known about their transcriptional dynamics and it is challenging to …
[HTML][HTML] Layer 4 of mouse neocortex differs in cell types and circuit organization between sensory areas
Layer 4 (L4) of mammalian neocortex plays a crucial role in cortical information processing,
yet a complete census of its cell types and connectivity remains elusive. Using whole-cell …
yet a complete census of its cell types and connectivity remains elusive. Using whole-cell …
Cell type composition and circuit organization of clonally related excitatory neurons in the juvenile mouse neocortex
Clones of excitatory neurons derived from a common progenitor have been proposed to serve
as elementary information processing modules in the neocortex. To characterize the cell …
as elementary information processing modules in the neocortex. To characterize the cell …
Genomic encoding of transcriptional burst kinetics
Mammalian gene expression is inherently stochastic 1 , 2 , and results in discrete bursts of
RNA molecules that are synthesized from each allele 3 , 4 , 5 , 6 – 7 . Although transcription is …
RNA molecules that are synthesized from each allele 3 , 4 , 5 , 6 – 7 . Although transcription is …
[HTML][HTML] Phenotypic variation of transcriptomic cell types in mouse motor cortex
Cortical neurons exhibit extreme diversity in gene expression as well as in morphological
and electrophysiological properties 1, 2. Most existing neural taxonomies are based on either …
and electrophysiological properties 1, 2. Most existing neural taxonomies are based on either …
[PDF][PDF] A DNA nanoassembly-based approach to map membrane protein nanoenvironments
Institutet, Stockholm, Sweden, 3Laboratory for Environmental and Life Sciences, University
of Nova Gorica, Nova Gorica, Slovenia. Super-resolution imaging has revealed that most …
of Nova Gorica, Nova Gorica, Slovenia. Super-resolution imaging has revealed that most …
[HTML][HTML] Microscale Bioreactors for in situ characterization of GI epithelial cell physiology
CM Costello, MB Phillipsen, LM Hartmanis… - Scientific reports, 2017 - nature.com
The development of in vitro artificial small intestines that realistically mimic in vivo systems
will enable vast improvement of our understanding of the human gut and its impact on human …
will enable vast improvement of our understanding of the human gut and its impact on human …
A multimodal cell census and atlas of the mammalian primary motor cortex
…, M Grauer, YO Halchenko, JA Harris, L Hartmanis… - Biorxiv, 2020 - biorxiv.org
We report the generation of a multimodal cell census and atlas of the mammalian primary
motor cortex (MOp or M1) as the initial product of the BRAIN Initiative Cell Census Network (…
motor cortex (MOp or M1) as the initial product of the BRAIN Initiative Cell Census Network (…
Neocortical layer 4 in adult mouse differs in major cell types and circuit organization between primary sensory areas
Layer 4 (L4) of mammalian neocortex plays a crucial role in cortical information processing,
yet a complete census of its cell types and connectivity remains elusive. Using whole-cell …
yet a complete census of its cell types and connectivity remains elusive. Using whole-cell …
[HTML][HTML] Compound models and Pearson residuals for normalization of single-cell RNA-seq data without UMIs
Before downstream analysis can reveal biological signals in single-cell RNA sequencing
data, normalization and variance stabilization are required to remove technical noise. Recently…
data, normalization and variance stabilization are required to remove technical noise. Recently…