[HTML][HTML] Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration
TM Tsarouchas, D Wehner, L Cavone, T Munir… - Nature …, 2018 - nature.com
Spinal cord injury leads to a massive response of innate immune cells in non-regenerating
mammals, but also in successfully regenerating zebrafish. However, the role of the immune …
mammals, but also in successfully regenerating zebrafish. However, the role of the immune …
Histone deacetylase (HDAC) inhibitors reduce the glial inflammatory response in vitro and in vivo
Histone deacetylase inhibitors (HDACi) are emerging tools for epigenetic modulation of
gene expression and suppress the inflammatory response in models of systemic immune …
gene expression and suppress the inflammatory response in models of systemic immune …
G-protein coupled receptor 35 (GPR35) activation and inflammatory pain: Studies on the antinociceptive effects of kynurenic acid and zaprinast
…, G Mannaioni, A Cozzi, V Carlà, M Sili, L Cavone… - …, 2011 - Elsevier
G-protein coupled receptor 35 (GPR35) is a former “orphan receptor” expressed in brain
and activated by either kynurenic acid or zaprinast. While zaprinast has been studied as a …
and activated by either kynurenic acid or zaprinast. While zaprinast has been studied as a …
[HTML][HTML] GPR35 Activation Reduces Ca2+ Transients and Contributes to the Kynurenic Acid-Dependent Reduction of Synaptic Activity at CA3-CA1 Synapses
R Berlinguer-Palmini, A Masi, R Narducci, L Cavone… - PloS one, 2013 - journals.plos.org
Limited information is available on the brain expression and role of GPR35, a Gi/o coupled
receptor activated by kynurenic acid (KYNA). In mouse cultured astrocytes, we detected …
receptor activated by kynurenic acid (KYNA). In mouse cultured astrocytes, we detected …
[HTML][HTML] The therapeutic potential of HDAC inhibitors in the treatment of multiple sclerosis
G Faraco, L Cavone, A Chiarugi - Molecular medicine, 2011 - Springer
Multiple sclerosis (MS) is a devastating autoimmune disorder of the central nervous system (CNS)
for which there is no efficacious cure. Thanks to numerous preclinical and clinical …
for which there is no efficacious cure. Thanks to numerous preclinical and clinical …
[PDF][PDF] A unique macrophage subpopulation signals directly to progenitor cells to promote regenerative neurogenesis in the zebrafish spinal cord
L Cavone, T McCann, LK Drake, EA Aguzzi… - Developmental cell, 2021 - cell.com
Central nervous system injury re-initiates neurogenesis in anamniotes (amphibians and
fishes), but not in mammals. Activation of the innate immune system promotes regenerative …
fishes), but not in mammals. Activation of the innate immune system promotes regenerative …
Functional study in a yeast model of a novel succinate dehydrogenase subunit B gene germline missense mutation (C191Y) diagnosed in a patient affected by a …
…, E Panizza, V Giache, L Cavone… - Human molecular …, 2009 - academic.oup.com
Mutations of succinate dehydrogenase (SDH) subunits B, C and D are associated to
pheochromocytoma/paraganglioma (PGL) development. The mechanisms linking SDH mutations to …
pheochromocytoma/paraganglioma (PGL) development. The mechanisms linking SDH mutations to …
[HTML][HTML] Dipotassium glycyrrhizate inhibits HMGB1-dependent inflammation and ameliorates colitis in mice
R Vitali, F Palone, S Cucchiara, A Negroni, L Cavone… - PloS one, 2013 - journals.plos.org
Background High mobility group box-1 (HMGB1) is a DNA-binding protein that is released
from injured cells during inflammation. Advances in targeting HMGB1 represent a major …
from injured cells during inflammation. Advances in targeting HMGB1 represent a major …
Ischemic neuroprotection by TRPV1 receptor-induced hypothermia
Although treatment of stroke patients with mild hypothermia is a promising therapeutic approach,
chemicals inducing prompt and safe reduction of body temperature are an unmet need. …
chemicals inducing prompt and safe reduction of body temperature are an unmet need. …
Dysregulation of sphingosine 1 phosphate receptor-1 (S1P1) signaling and regulatory lymphocyte-dependent immunosuppression in a model of post-fingolimod MS …
L Cavone, R Felici, A Lapucci, D Buonvicino… - Brain, behavior, and …, 2015 - Elsevier
Fingolimod affords protection from MS by sequestering lymphocytes in secondary lymphoid
organs via down regulation of their sphingosine 1 phosphate receptor (S1P1). Unexpectedly…
organs via down regulation of their sphingosine 1 phosphate receptor (S1P1). Unexpectedly…