User profiles for Leonardo E Valdivia

Leonardo E. Valdivia

Center for Integrative Biology (CIB), Facultad de Ciencias, Universidad Mayor de Chile
Verified email at umayor.cl
Cited by 998

[HTML][HTML] Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism–dystonia

K Tuschl, E Meyer, LE Valdivia, N Zhao… - Nature …, 2016 - nature.com
Although manganese is an essential trace metal, little is known about its transport and
homeostatic regulation. Here we have identified a cohort of patients with a novel autosomal …

[HTML][HTML] In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains

…, D Bournele, A Domenichini, LE Valdivia… - Developmental …, 2012 - Elsevier
The creation of molecular tools able to unravel in vivo spatiotemporal activation of specific
cell signaling events during cell migration, differentiation and morphogenesis is of great …

Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo

AM Krasnow, MC Ford, LE Valdivia, SW Wilson… - Nature …, 2018 - nature.com
How action potentials regulate myelination by oligodendrocytes is uncertain. We show that
neuronal activity raises [Ca 2+ ] i in developing oligodendrocytes in vivo and that myelin …

The oculome panel test: next-generation sequencing to diagnose a diverse range of genetic developmental eye disorders

…, L Islam, M Bitner-Glindzicz, J Hurst, LE Valdivia… - Ophthalmology, 2019 - Elsevier
Purpose To develop a comprehensive next-generation sequencing panel assay that screens
genes known to cause developmental eye disorders and inherited eye disease and to …

Lef1-dependent Wnt/β-catenin signalling drives the proliferative engine that maintains tissue homeostasis during lateral line development

LE Valdivia, RM Young, TA Hawkins… - …, 2011 - journals.biologists.com
During tissue morphogenesis and differentiation, cells must self-renew while contemporaneously
generating daughters that contribute to the growing tissue. How tissues achieve this …

Antagonism between Gdf6a and retinoic acid pathways controls timing of retinal neurogenesis and growth of the eye in zebrafish

LE Valdivia, DB Lamb, W Horner, C Wierzbicki… - …, 2016 - journals.biologists.com
Maintaining neurogenesis in growing tissues requires a tight balance between progenitor cell
proliferation and differentiation. In the zebrafish retina, neuronal differentiation proceeds in …

[HTML][HTML] Fishing forward and reverse: Advances in zebrafish phenomics

R Fuentes, J Letelier, B Tajer, LE Valdivia… - Mechanisms of …, 2018 - Elsevier
Understanding how the genome instructs the phenotypic characteristics of an organism is
one of the major scientific endeavors of our time. Advances in genetics have progressively …

[HTML][HTML] Watching eyes take shape

N Bazin-Lopez, LE Valdivia, SW Wilson… - Current opinion in …, 2015 - Elsevier
Vertebrate eye formation is a multistep process requiring coordinated inductive interactions
between neural and non-neural ectoderm and underlying mesendoderm. The induction and …

Loss of slc39a14 causes simultaneous manganese hypersensitivity and deficiency in zebrafish

…, RJ White, C Trivedi, LE Valdivia… - Disease Models & …, 2022 - journals.biologists.com
Manganese neurotoxicity is a hallmark of hypermanganesemia with dystonia 2, an inherited
manganese transporter defect caused by mutations in SLC39A14. To identify novel …

[HTML][HTML] Axon-Schwann cell interactions during peripheral nerve regeneration in zebrafish larvae

…, C Mardones-Krsulovic, M Sánchez, LE Valdivia… - Neural …, 2014 - Springer
Background Peripheral nerve injuries can severely affect the way that animals perceive
signals from the surrounding environment. While damage to peripheral axons generally has a …