User profiles for Leonardo E Valdivia
Leonardo E. ValdiviaCenter for Integrative Biology (CIB), Facultad de Ciencias, Universidad Mayor de Chile Verified email at umayor.cl Cited by 998 |
[HTML][HTML] Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism–dystonia
Although manganese is an essential trace metal, little is known about its transport and
homeostatic regulation. Here we have identified a cohort of patients with a novel autosomal …
homeostatic regulation. Here we have identified a cohort of patients with a novel autosomal …
[HTML][HTML] In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains
…, D Bournele, A Domenichini, LE Valdivia… - Developmental …, 2012 - Elsevier
The creation of molecular tools able to unravel in vivo spatiotemporal activation of specific
cell signaling events during cell migration, differentiation and morphogenesis is of great …
cell signaling events during cell migration, differentiation and morphogenesis is of great …
Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo
How action potentials regulate myelination by oligodendrocytes is uncertain. We show that
neuronal activity raises [Ca 2+ ] i in developing oligodendrocytes in vivo and that myelin …
neuronal activity raises [Ca 2+ ] i in developing oligodendrocytes in vivo and that myelin …
The oculome panel test: next-generation sequencing to diagnose a diverse range of genetic developmental eye disorders
…, L Islam, M Bitner-Glindzicz, J Hurst, LE Valdivia… - Ophthalmology, 2019 - Elsevier
Purpose To develop a comprehensive next-generation sequencing panel assay that screens
genes known to cause developmental eye disorders and inherited eye disease and to …
genes known to cause developmental eye disorders and inherited eye disease and to …
Lef1-dependent Wnt/β-catenin signalling drives the proliferative engine that maintains tissue homeostasis during lateral line development
During tissue morphogenesis and differentiation, cells must self-renew while contemporaneously
generating daughters that contribute to the growing tissue. How tissues achieve this …
generating daughters that contribute to the growing tissue. How tissues achieve this …
Antagonism between Gdf6a and retinoic acid pathways controls timing of retinal neurogenesis and growth of the eye in zebrafish
LE Valdivia, DB Lamb, W Horner, C Wierzbicki… - …, 2016 - journals.biologists.com
Maintaining neurogenesis in growing tissues requires a tight balance between progenitor cell
proliferation and differentiation. In the zebrafish retina, neuronal differentiation proceeds in …
proliferation and differentiation. In the zebrafish retina, neuronal differentiation proceeds in …
[HTML][HTML] Fishing forward and reverse: Advances in zebrafish phenomics
Understanding how the genome instructs the phenotypic characteristics of an organism is
one of the major scientific endeavors of our time. Advances in genetics have progressively …
one of the major scientific endeavors of our time. Advances in genetics have progressively …
[HTML][HTML] Watching eyes take shape
N Bazin-Lopez, LE Valdivia, SW Wilson… - Current opinion in …, 2015 - Elsevier
Vertebrate eye formation is a multistep process requiring coordinated inductive interactions
between neural and non-neural ectoderm and underlying mesendoderm. The induction and …
between neural and non-neural ectoderm and underlying mesendoderm. The induction and …
Loss of slc39a14 causes simultaneous manganese hypersensitivity and deficiency in zebrafish
Manganese neurotoxicity is a hallmark of hypermanganesemia with dystonia 2, an inherited
manganese transporter defect caused by mutations in SLC39A14. To identify novel …
manganese transporter defect caused by mutations in SLC39A14. To identify novel …
[HTML][HTML] Axon-Schwann cell interactions during peripheral nerve regeneration in zebrafish larvae
…, C Mardones-Krsulovic, M Sánchez, LE Valdivia… - Neural …, 2014 - Springer
Background Peripheral nerve injuries can severely affect the way that animals perceive
signals from the surrounding environment. While damage to peripheral axons generally has a …
signals from the surrounding environment. While damage to peripheral axons generally has a …