User profiles for Leong-Keat Chan
Leong-Keat ChanPostdoctoral Fellow, DOE Joint Genome Institute, Walnut Creek, CA, USA Verified email at lbl.gov Cited by 191 |
Sizing up metatranscriptomics
A typical marine bacterial cell in coastal seawater contains only ∼200 molecules of mRNA,
each of which lasts only a few minutes before being degraded. Such a surprisingly small and …
each of which lasts only a few minutes before being degraded. Such a surprisingly small and …
Genome-wide selective sweeps and gene-specific sweeps in natural bacterial populations
ML Bendall, SLR Stevens, LK Chan, S Malfatti… - The ISME …, 2016 - academic.oup.com
Multiple models describe the formation and evolution of distinct microbial phylogenetic
groups. These evolutionary models make different predictions regarding how adaptive alleles …
groups. These evolutionary models make different predictions regarding how adaptive alleles …
Comparative single-cell genomics reveals potential ecological niches for the freshwater acI Actinobacteria lineage
…, J Mutschler, J Dwulit-Smith, LK Chan… - The ISME …, 2014 - academic.oup.com
Members of the acI lineage of Actinobacteria are the most abundant microorganisms in most
freshwater lakes; however, our understanding of the keys to their success and their role in …
freshwater lakes; however, our understanding of the keys to their success and their role in …
[HTML][HTML] Nanogrid single-nucleus RNA sequencing reveals phenotypic diversity in breast cancer
…, C Kim, E Sei, T Foukakis, N Crosetto, LK Chan… - Nature …, 2017 - nature.com
Single cell RNA sequencing has emerged as a powerful tool for resolving transcriptional
diversity in tumors, but is limited by throughput, cost and the ability to process archival frozen …
diversity in tumors, but is limited by throughput, cost and the ability to process archival frozen …
[HTML][HTML] Ecogenomics of virophages and their giant virus hosts assessed through time series metagenomics
S Roux, LK Chan, R Egan, RR Malmstrom… - Nature …, 2017 - nature.com
Virophages are small viruses that co-infect eukaryotic cells alongside giant viruses (Mimiviridae)
and hijack their machinery to replicate. While two types of virophages have been …
and hijack their machinery to replicate. While two types of virophages have been …
Ecophysiology of freshwater Verrucomicrobia inferred from metagenome-assembled genomes
Microbes are critical in carbon and nutrient cycling in freshwater ecosystems. Members of the
Verrucomicrobia are ubiquitous in such systems, and yet their roles and ecophysiology are …
Verrucomicrobia are ubiquitous in such systems, and yet their roles and ecophysiology are …
Functional Analysis of Three Sulfide:Quinone Oxidoreductase Homologs in Chlorobaculum tepidum
Sulfide:quinone oxidoreductase (SQR) catalyzes sulfide oxidation during sulfide-dependent
chemo- and phototrophic growth in bacteria. The green sulfur bacterium Chlorobaculum …
chemo- and phototrophic growth in bacteria. The green sulfur bacterium Chlorobaculum …
A genomic region required for phototrophic thiosulfate oxidation in the green sulfur bacterium Chlorobium tepidum (syn. Chlorobaculum tepidum)
LK Chan, TS Weber, RM Morgan-Kiss… - …, 2008 - microbiologyresearch.org
The specific enzymes employed by Chlorobium tepidum for the anaerobic oxidation of thiosulfate,
sulfide and elemental sulfur during anoxygenic photosynthesis are not well defined. In …
sulfide and elemental sulfur during anoxygenic photosynthesis are not well defined. In …
[HTML][HTML] Transcriptional changes underlying elemental stoichiometry shifts in a marine heterotrophic bacterium
Marine bacteria drive the biogeochemical processing of oceanic dissolved organic carbon (DOC),
a 750-Tg C reservoir that is a critical component of the global C cycle. Catabolism of …
a 750-Tg C reservoir that is a critical component of the global C cycle. Catabolism of …
[HTML][HTML] Experimental identification of small non-coding RNAs in the model marine bacterium Ruegeria pomeroyi DSS-3
In oligotrophic ocean waters where bacteria are often subjected to chronic nutrient limitation,
community transcriptome sequencing has pointed to the presence of highly abundant small …
community transcriptome sequencing has pointed to the presence of highly abundant small …