User profiles for Leong-Keat Chan

Leong-Keat Chan

Postdoctoral Fellow, DOE Joint Genome Institute, Walnut Creek, CA, USA
Verified email at lbl.gov
Cited by 191

Sizing up metatranscriptomics

…, SM Gifford, H Luo, A Rivers, LK Chan… - The ISME …, 2013 - academic.oup.com
A typical marine bacterial cell in coastal seawater contains only ∼200 molecules of mRNA,
each of which lasts only a few minutes before being degraded. Such a surprisingly small and …

Genome-wide selective sweeps and gene-specific sweeps in natural bacterial populations

ML Bendall, SLR Stevens, LK Chan, S Malfatti… - The ISME …, 2016 - academic.oup.com
Multiple models describe the formation and evolution of distinct microbial phylogenetic
groups. These evolutionary models make different predictions regarding how adaptive alleles …

Comparative single-cell genomics reveals potential ecological niches for the freshwater acI Actinobacteria lineage

…, J Mutschler, J Dwulit-Smith, LK Chan… - The ISME …, 2014 - academic.oup.com
Members of the acI lineage of Actinobacteria are the most abundant microorganisms in most
freshwater lakes; however, our understanding of the keys to their success and their role in …

[HTML][HTML] Nanogrid single-nucleus RNA sequencing reveals phenotypic diversity in breast cancer

…, C Kim, E Sei, T Foukakis, N Crosetto, LK Chan… - Nature …, 2017 - nature.com
Single cell RNA sequencing has emerged as a powerful tool for resolving transcriptional
diversity in tumors, but is limited by throughput, cost and the ability to process archival frozen …

[HTML][HTML] Ecogenomics of virophages and their giant virus hosts assessed through time series metagenomics

S Roux, LK Chan, R Egan, RR Malmstrom… - Nature …, 2017 - nature.com
Virophages are small viruses that co-infect eukaryotic cells alongside giant viruses (Mimiviridae)
and hijack their machinery to replicate. While two types of virophages have been …

Ecophysiology of freshwater Verrucomicrobia inferred from metagenome-assembled genomes

S He, SLR Stevens, LK Chan, S Bertilsson… - Msphere, 2017 - Am Soc Microbiol
Microbes are critical in carbon and nutrient cycling in freshwater ecosystems. Members of the
Verrucomicrobia are ubiquitous in such systems, and yet their roles and ecophysiology are …

Functional Analysis of Three Sulfide:Quinone Oxidoreductase Homologs in Chlorobaculum tepidum

LK Chan, RM Morgan-Kiss, TE Hanson - Journal of bacteriology, 2009 - Am Soc Microbiol
Sulfide:quinone oxidoreductase (SQR) catalyzes sulfide oxidation during sulfide-dependent
chemo- and phototrophic growth in bacteria. The green sulfur bacterium Chlorobaculum …

A genomic region required for phototrophic thiosulfate oxidation in the green sulfur bacterium Chlorobium tepidum (syn. Chlorobaculum tepidum)

LK Chan, TS Weber, RM Morgan-Kiss… - …, 2008 - microbiologyresearch.org
The specific enzymes employed by Chlorobium tepidum for the anaerobic oxidation of thiosulfate,
sulfide and elemental sulfur during anoxygenic photosynthesis are not well defined. In …

[HTML][HTML] Transcriptional changes underlying elemental stoichiometry shifts in a marine heterotrophic bacterium

LK Chan, RJ Newton, S Sharma, CB Smith… - Frontiers in …, 2012 - frontiersin.org
Marine bacteria drive the biogeochemical processing of oceanic dissolved organic carbon (DOC),
a 750-Tg C reservoir that is a critical component of the global C cycle. Catabolism of …

[HTML][HTML] Experimental identification of small non-coding RNAs in the model marine bacterium Ruegeria pomeroyi DSS-3

AR Rivers, AS Burns, LK Chan, MA Moran - Frontiers in Microbiology, 2016 - frontiersin.org
In oligotrophic ocean waters where bacteria are often subjected to chronic nutrient limitation,
community transcriptome sequencing has pointed to the presence of highly abundant small …