[HTML][HTML] Extracting biological age from biomedical data via deep learning: too much of a good thing?
Age-related physiological changes in humans are linearly associated with age. Naturally,
linear combinations of physiological measures trained to estimate chronological age have …
linear combinations of physiological measures trained to estimate chronological age have …
[HTML][HTML] Longitudinal analysis of blood markers reveals progressive loss of resilience and predicts human lifespan limit
…, K Avchaciov, AE Tarkhov, LI Menshikov… - Nature …, 2021 - nature.com
We investigated the dynamic properties of the organism state fluctuations along individual
aging trajectories in a large longitudinal database of CBC measurements from a consumer …
aging trajectories in a large longitudinal database of CBC measurements from a consumer …
[HTML][HTML] A universal transcriptomic signature of age reveals the temporal scaling of Caenorhabditis elegans aging trajectories
…, R Alla, S Ayyadevara, M Pyatnitskiy, LI Menshikov… - Scientific reports, 2019 - nature.com
We collected 60 age-dependent transcriptomes for C. elegans strains including four exceptionally
long-lived mutants (mean adult lifespan extended 2.2- to 9.4-fold) and three examples …
long-lived mutants (mean adult lifespan extended 2.2- to 9.4-fold) and three examples …
[HTML][HTML] Unsupervised learning of aging principles from longitudinal data
…, EL Andrianova, AE Tarkhov, LI Menshikov… - Nature …, 2022 - nature.com
Age is the leading risk factor for prevalent diseases and death. However, the relation
between age-related physiological changes and lifespan is poorly understood. We combined …
between age-related physiological changes and lifespan is poorly understood. We combined …
[HTML][HTML] Quantitative characterization of biological age and frailty based on locomotor activity records
…, K Avchaciov, M Pyatnitskiy, L Menshikov… - Aging (Albany …, 2018 - ncbi.nlm.nih.gov
We performed a systematic evaluation of the relationships between locomotor activity and
signatures of frailty, morbidity, and mortality risks using physical activity records from the 2003-…
signatures of frailty, morbidity, and mortality risks using physical activity records from the 2003-…
[HTML][HTML] Stability analysis of a model gene network links aging, stress resistance and negligible senescence
Several animal species are considered to exhibit what is called negligible senescence, ie
they do not show signs of functional decline or any increase of mortality with age. Recent …
they do not show signs of functional decline or any increase of mortality with age. Recent …
[HTML][HTML] Strehler-Mildvan correlation is a degenerate manifold of Gompertz fit
AE Tarkhov, LI Menshikov, PO Fedichev - Journal of theoretical biology, 2017 - Elsevier
Gompertz empirical law of mortality is often used in practical research to parametrize survival
fraction as a function of age with the help of just two quantities: the Initial Mortality Rate (IMR…
fraction as a function of age with the help of just two quantities: the Initial Mortality Rate (IMR…
Experimental evidence of the ferroelectric nature of the λ-point transition in liquid water
PO Fedichev, LI Menshikov, GS Bordonskiy, AO Orlov - JETP letters, 2011 - Springer
We studied the dielectric properties of nano-sized liquid water samples confined in
polymerized silicates MCM-41 characterized by pore sizes 3–10 nm. Freezing temperature …
polymerized silicates MCM-41 characterized by pore sizes 3–10 nm. Freezing temperature …
Identification of a blood test-based biomarker of aging through deep learning of aging trajectories in large phenotypic datasets of mice
…, MP Antoch, EL Andrianova, AE Tarkhov, LI Menshikov… - bioRxiv, 2020 - biorxiv.org
We proposed and characterized a novel biomarker of aging and frailty in mice trained from
the large set of the most conventional, easily measured blood parameters such as Complete …
the large set of the most conventional, easily measured blood parameters such as Complete …
Critical dynamics of gene networks is a mechanism behind ageing and Gompertz law
Although accumulation of molecular damage is suggested to be an important molecular
mechanism of aging, a quantitative link between the dynamics of damage accumulation and …
mechanism of aging, a quantitative link between the dynamics of damage accumulation and …