Can vitamin A be improved to prevent blindness due to age-related macular degeneration, Stargardt disease and other retinal dystrophies?
L Saad, I Washington - Retinal degenerative diseases: mechanisms and …, 2016 - Springer
We discuss how an imperfect visual cycle results in the formation of vitamin A dimers,
thought to be involved in the pathogenesis of various retinal diseases, and summarize how …
thought to be involved in the pathogenesis of various retinal diseases, and summarize how …
[HTML][HTML] ALK-001 (C20-D3-Vitamin A) slows the growth of atrophic lesions in ABCA4-related Stargardt Disease: Results of a Phase 2 placebo-controlled clinical trial …
…, I Washington, L Saad - … & Visual Science, 2022 - iovs.arvojournals.org
Purpose: To study the effects of ALK-001 on the progression of Stargardt Disease (STGD1).
STGD1 is the most prevalent inherited macular dystrophy and results from defects in the …
STGD1 is the most prevalent inherited macular dystrophy and results from defects in the …
Percentage of foveal vs total macular geographic atrophy as a predictor of visual acuity in age-related macular degeneration
Purpose: This article investigates the relationship between visual acuity (VA), total area of
geographic atrophy (GA), and percentage of foveal GA. Methods: A multicenter, retrospective, …
geographic atrophy (GA), and percentage of foveal GA. Methods: A multicenter, retrospective, …
[HTML][HTML] Stargardt disease ALK-001 phase 2 clinical trial: 12-month interim data
…, I Washington, L Saad - … & Visual Science, 2019 - iovs.arvojournals.org
Purpose: Stargardt disease (STGD1) is the most prevalent inherited macular dystrophy. In
the absence of an approved treatment, there is a growing interest and need for well-designed …
the absence of an approved treatment, there is a growing interest and need for well-designed …
[HTML][HTML] Vitamin A cycle byproducts impede dark adaptation
D Zhang, K Robinson, L Saad, I Washington - Journal of Biological …, 2021 - ASBMB
Impaired dark adaptation (DA), a defect in the ability to adjust to dimly lit settings, is a universal
hallmark of aging. However, the mechanisms responsible for impaired DA are poorly …
hallmark of aging. However, the mechanisms responsible for impaired DA are poorly …
The rate of vitamin A dimerization in lipofuscinogenesis, fundus autofluorescence, retinal senescence and degeneration
I Washington, L Saad - Retinal Degenerative Diseases: Mechanisms and …, 2016 - Springer
One of the earliest events preceding several forms of retinal degeneration is the formation
and accumulation of vitamin A dimers in the retinal pigment epithelium (RPE) and underlying …
and accumulation of vitamin A dimers in the retinal pigment epithelium (RPE) and underlying …
[HTML][HTML] Stargardt Disease Phase 2 Clinical Trial: design and baseline characteristics
…, MB Gorin, I Washington, L Saad - … & Visual Science, 2017 - iovs.arvojournals.org
Purpose: Stargardt disease (STGD) is the most frequent inherited macular dystrophy. The
disease results from defects in the ABCA4 gene, which accelerate the formation of …
disease results from defects in the ABCA4 gene, which accelerate the formation of …
A collagen based scaffold for the repair of annulus fibrosus defects
LC Saad - 2007 - dspace.mit.edu
The intervertebral disc (IVD) is the natural cartilaginous cushion found between the osseous
vertebrae of the spinal column. It is an essential element for the flexibility of the spine but …
vertebrae of the spinal column. It is an essential element for the flexibility of the spine but …
[PDF][PDF] Effects of collagen type on the behavior of annulus fibrosus cells from the canine intervertebral disc in collagen-glycosaminoglycan matrices
LC Saad - 2002 - dspace.mit.edu
The intervertebral disc (IVD) is the natural cartilaginous cushion found between the osseous
vertebrae of the spinal column. It is an essential element for the flexibility of the spinal …
vertebrae of the spinal column. It is an essential element for the flexibility of the spinal …
P71. Effects of TGF-β1 and FGF-2 on the biosynthetic activity of annulus fibrosus cells grown in a type ii collagen-gag scaffold for tissue engineering
L Saad, M Spector - The Spine Journal, 2003 - thespinejournalonline.com
METHODS: AF cells were enzymatically isolated from 6 adult dogs and expanded separately
through 4 passages in 20% FBS medium. Nine-mm diameter discs of freeze-dried type II …
through 4 passages in 20% FBS medium. Nine-mm diameter discs of freeze-dried type II …