Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin
gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis …

Background Most patients with Parkinson's disease, Parkinson's disease dementia, and
dementia with Lewy bodies do not carry mutations in known disease-causing genes. The aim of …

Parkinson’s disease (PD) is a progressive neurodegenerative disorder known for the typical
motor features associated. Pathologically, it is characterized by the intracellular …

ABSTRACT: Background Essential tremor (ET) is a very common movement disorder that
has no diagnostic markers. Differentiation with Parkinson's disease (PD) can be clinically …

Introduction Mutations in the GBA gene, encoding for the lysosomal enzyme glucocerebrosidase,
are associated with Gaucher disease. Alterations in plasma sphingolipids have been …

Background Over the past decades there has been a significant increase in the number of
published clinical trials in palliative care. However, empirical evidence suggests that there are …

Background Late-stage Parkinson’ disease (PD) is dominated by loss of autonomy due to
motor and non-motor symptoms which can be marginally corrected by medications …

Background Huntington's disease ( HD ) is a rare and fatal inherited genetic disorder
characterized by progressive motor, cognitive, and behavioral impairment. It leads to premature …

Mutations in the Leucine‐Rich Repeat Kinase 2 (LRRK2) gene are the most frequent known
cause of Parkinson's disease (PD), but their prevalence varies markedly between …

Background Parkinson’s disease (PD) patients are affected by hypokinetic dysarthria,
characterized by hypophonia and dysprosody, which worsens with disease progression. Levodopa…