User profiles for Leslie S. Emery
Leslie S. EmeryBristol Myers Squibb Verified email at bms.com Cited by 2139 |
[HTML][HTML] Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program
The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
We assembled an ancestrally diverse collection of genome-wide association studies (GWAS)
of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non…
of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non…
[PDF][PDF] Associations of mitochondrial and nuclear mitochondrial variants and genes with seven metabolic traits
Mitochondria (MT), the major site of cellular energy production, are under dual genetic control
by 37 mitochondrial DNA (mtDNA) genes and numerous nuclear genes (MT-nDNA). In the …
by 37 mitochondrial DNA (mtDNA) genes and numerous nuclear genes (MT-nDNA). In the …
Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential
Human genetic studies support an inverse causal relationship between leukocyte telomere
length (LTL) and coronary artery disease (CAD), but directionally mixed effects for LTL and …
length (LTL) and coronary artery disease (CAD), but directionally mixed effects for LTL and …
Population sequencing data reveal a compendium of mutational processes in the human germ line
Biological mechanisms underlying human germline mutations remain largely unknown. We
statistically decompose variation in the rate and spectra of mutations along the genome …
statistically decompose variation in the rate and spectra of mutations along the genome …
A system for phenotype harmonization in the national heart, lung, and blood institute trans-omics for precision medicine (TOPMed) program
AM Stilp, LS Emery, JG Broome, EJ Buth… - American journal of …, 2021 - academic.oup.com
Genotype-phenotype association studies often combine phenotype data from multiple studies
to increase statistical power. Harmonization of the data usually requires substantial effort …
to increase statistical power. Harmonization of the data usually requires substantial effort …
[HTML][HTML] Multi-ancestry genome-wide study in> 2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse
pathophysiological processes. To characterise the genetic contribution to these processes across …
pathophysiological processes. To characterise the genetic contribution to these processes across …
Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
We assembled an ancestrally diverse collection of genome-wide association studies of type
2 diabetes (T2D) in 180,834 cases and 1,159,055 controls (48.9% non-European descent). …
2 diabetes (T2D) in 180,834 cases and 1,159,055 controls (48.9% non-European descent). …
[PDF][PDF] Rare coding variants in 35 genes associate with circulating lipid levels—A multi-ancestry analysis of 170,000 exomes
Large-scale gene sequencing studies for complex traits have the potential to identify causal
genes with therapeutic implications. We performed gene-based association testing of blood …
genes with therapeutic implications. We performed gene-based association testing of blood …
[HTML][HTML] Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices
Autosomal genetic analyses of blood lipids have yielded key insights for coronary heart
disease (CHD). However, X chromosome genetic variation is understudied for blood lipids in …
disease (CHD). However, X chromosome genetic variation is understudied for blood lipids in …