User profiles for Leticia P Roma

Leticia Prates Roma

Biophysics Professor Saarland University
Verified email at uks.eu
Cited by 1876

Nutrient metabolism, subcellular redox state, and oxidative stress in pancreatic islets and β-cells

LP Roma, JC Jonas - Journal of molecular biology, 2020 - Elsevier
Insulin-secreting pancreatic β-cells play a critical role in blood glucose homeostasis and the
development of type 2 diabetes (T2D) in the context of insulin resistance. Based on data …

[HTML][HTML] Vitamin A-retinoic acid signaling regulates hematopoietic stem cell dormancy

…, D Pastor-Flores, LP Roma, S Renders, P Zeisberger… - Cell, 2017 - cell.com
Dormant hematopoietic stem cells (dHSCs) are atop the hematopoietic hierarchy. The
molecular identity of dHSCs and the mechanisms regulating their maintenance or exit from …

Improvement of islet transplantation by the fusion of islet cells with functional blood vessels

L Nalbach, LP Roma, BM Schmitt, V Becker… - EMBO molecular …, 2021 - embopress.org
Pancreatic islet transplantation still represents a promising therapeutic strategy for curative
treatment of type 1 diabetes mellitus. However, a limited number of organ donors and …

Mouse redox histology using genetically encoded probes

Y Fujikawa, LP Roma, MC Sobotta, AJ Rose… - Science …, 2016 - science.org
Mapping the in vivo distribution of endogenous oxidants in animal tissues is of substantial
biomedical interest. Numerous health-related factors, including diet, physical activity, infection, …

Dynamic measurements of mitochondrial hydrogen peroxide concentration and glutathione redox state in rat pancreatic β-cells using ratiometric fluorescent proteins …

LP Roma, J Duprez, HK Takahashi, P Gilon… - Biochemical …, 2012 - portlandpress.com
Leticia Roma and Jean-Christophe Jonas conceived and designed the experiments;
Leticia Roma and Jessica Duprez performed the experiments; Leticia Roma and Jean-Christophe …

[HTML][HTML] Protective Antioxidant and Antiapoptotic Effects of ZnCl2 in Rat Pancreatic Islets Cultured in Low and High Glucose Concentrations

J Duprez, LP Roma, AF Close, JC Jonas - 2012 - journals.plos.org
Aim/Hypothesis Rat pancreatic islet cell apoptosis is minimal after prolonged culture in 10
mmol/l glucose (G10), largely increased in 5 mmol/l glucose (G5) and moderately increased in …

[HTML][HTML] A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding

…, S Aggarwal, AR Pepper, LP Roma… - Nature …, 2024 - nature.com
Pancreatic β-cells respond to metabolic stress by upregulating insulin secretion, however the
underlying mechanisms remain unclear. Here we show, in β-cells from overweight humans …

Endothelial Notch signaling controls insulin transport in muscle

…, V Nordström, G Federico, LP Roma… - EMBO molecular …, 2020 - embopress.org
The role of the endothelium is not just limited to acting as an inert barrier for facilitating
blood transport. Endothelial cells ( EC s), through expression of a repertoire of angiocrine …

Acute nutrient regulation of the mitochondrial glutathione redox state in pancreatic β-cells

HK Takahashi, LRB Santos, LP Roma… - Biochemical …, 2014 - portlandpress.com
The glucose stimulation of insulin secretion by pancreatic β-cells depends on increased
production of metabolic coupling factors, among which changes in NADPH and ROS (reactive …

[HTML][HTML] Mitochondrial oxidative stress contributes differently to rat pancreatic islet cell apoptosis and insulin secretory defects after prolonged culture in a low non …

LP Roma, SM Pascal, J Duprez, JC Jonas - Diabetologia, 2012 - Springer
Aims/hypothesis Pancreatic beta cells chronically exposed to low glucose concentrations
show signs of oxidative stress, loss of glucose-stimulated insulin secretion (GSIS) and …