User profiles for Leticia P Roma
Leticia Prates RomaBiophysics Professor Saarland University Verified email at uks.eu Cited by 1876 |
Nutrient metabolism, subcellular redox state, and oxidative stress in pancreatic islets and β-cells
Insulin-secreting pancreatic β-cells play a critical role in blood glucose homeostasis and the
development of type 2 diabetes (T2D) in the context of insulin resistance. Based on data …
development of type 2 diabetes (T2D) in the context of insulin resistance. Based on data …
[HTML][HTML] Vitamin A-retinoic acid signaling regulates hematopoietic stem cell dormancy
Dormant hematopoietic stem cells (dHSCs) are atop the hematopoietic hierarchy. The
molecular identity of dHSCs and the mechanisms regulating their maintenance or exit from …
molecular identity of dHSCs and the mechanisms regulating their maintenance or exit from …
Improvement of islet transplantation by the fusion of islet cells with functional blood vessels
L Nalbach, LP Roma, BM Schmitt, V Becker… - EMBO molecular …, 2021 - embopress.org
Pancreatic islet transplantation still represents a promising therapeutic strategy for curative
treatment of type 1 diabetes mellitus. However, a limited number of organ donors and …
treatment of type 1 diabetes mellitus. However, a limited number of organ donors and …
Mouse redox histology using genetically encoded probes
Mapping the in vivo distribution of endogenous oxidants in animal tissues is of substantial
biomedical interest. Numerous health-related factors, including diet, physical activity, infection, …
biomedical interest. Numerous health-related factors, including diet, physical activity, infection, …
Dynamic measurements of mitochondrial hydrogen peroxide concentration and glutathione redox state in rat pancreatic β-cells using ratiometric fluorescent proteins …
… Leticia Roma and Jean-Christophe Jonas conceived and designed the experiments;
Leticia Roma and Jessica Duprez performed the experiments; Leticia Roma and Jean-Christophe …
Leticia Roma and Jessica Duprez performed the experiments; Leticia Roma and Jean-Christophe …
[HTML][HTML] Protective Antioxidant and Antiapoptotic Effects of ZnCl2 in Rat Pancreatic Islets Cultured in Low and High Glucose Concentrations
Aim/Hypothesis Rat pancreatic islet cell apoptosis is minimal after prolonged culture in 10
mmol/l glucose (G10), largely increased in 5 mmol/l glucose (G5) and moderately increased in …
mmol/l glucose (G10), largely increased in 5 mmol/l glucose (G5) and moderately increased in …
[HTML][HTML] A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding
Pancreatic β-cells respond to metabolic stress by upregulating insulin secretion, however the
underlying mechanisms remain unclear. Here we show, in β-cells from overweight humans …
underlying mechanisms remain unclear. Here we show, in β-cells from overweight humans …
Endothelial Notch signaling controls insulin transport in muscle
…, V Nordström, G Federico, LP Roma… - EMBO molecular …, 2020 - embopress.org
The role of the endothelium is not just limited to acting as an inert barrier for facilitating
blood transport. Endothelial cells ( EC s), through expression of a repertoire of angiocrine …
blood transport. Endothelial cells ( EC s), through expression of a repertoire of angiocrine …
Acute nutrient regulation of the mitochondrial glutathione redox state in pancreatic β-cells
HK Takahashi, LRB Santos, LP Roma… - Biochemical …, 2014 - portlandpress.com
The glucose stimulation of insulin secretion by pancreatic β-cells depends on increased
production of metabolic coupling factors, among which changes in NADPH and ROS (reactive …
production of metabolic coupling factors, among which changes in NADPH and ROS (reactive …
[HTML][HTML] Mitochondrial oxidative stress contributes differently to rat pancreatic islet cell apoptosis and insulin secretory defects after prolonged culture in a low non …
Aims/hypothesis Pancreatic beta cells chronically exposed to low glucose concentrations
show signs of oxidative stress, loss of glucose-stimulated insulin secretion (GSIS) and …
show signs of oxidative stress, loss of glucose-stimulated insulin secretion (GSIS) and …