We performed a meta-analysis of 14 genome-wide association studies of coronary artery
disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of …

Obesity results from the interaction of genetic and environmental factors. To search for sequence
variants that affect variation in two common measures of obesity, weight and body mass …

The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …

Background Platelet glycoprotein IIb/IIIa is a membrane receptor for fibrinogen and von
Willebrand factor, and it has an important role in platelet aggregation. It is known to be involved …

Age is the dominant risk factor for most chronic human diseases, but the mechanisms
through which ageing confers this risk are largely unknown 1 . The age-related acquisition of …

Adult human height is one of the classical complex human traits 1 . We searched for sequence
variants that affect height by scanning the genomes of 25,174 Icelanders, 2,876 Dutch, …

Background— Nearly half of patients with heart failure have a preserved ejection fraction (HFpEF).
Symptoms of exercise intolerance and dyspnea are most often attributed to diastolic …

Background—Microvascular obstruction within an area of myocardial infarction indicates
worse functional recovery and a higher risk of postinfarction complications. After prolonged …

NO ⋅ is a free radical that modulates heart function and metabolism. We report that a
neuronal-type NO synthase (NOS) is located on cardiac sarcoplasmic reticulum (SR) membrane …

Background Contrast-enhanced fast magnetic resonance (MR) images of acute, reperfused
human infarcts demonstrate regions of hypoenhancement and hyperenhancement. The …