Monocytic MDSCs exhibit superior immune suppression via adenosine and depletion of adenosine improves efficacy of immunotherapy

…, LC Chew, B Stamp, X Zhang, A Whitt, C Li… - Science …, 2023 - science.org
Immune checkpoint inhibitor (ICI) therapy is effective against many cancers for a subset of
patients; a large percentage of patients remain unresponsive to this therapy. One contributing …

K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification

…, L Hunsicker, M Klag, S Klahr, C Lewis… - American Journal of …, 2002 - jhu.pure.elsevier.com
Introduction: Chronic kidney disease as a public health problem. Chronic kidney disease is
a worldwide public health problem. In the United States, there is a rising incidence and …

Tumor-educated monocytes suppress T cells via adenosine and depletion of adenosine in the tumor microenvironment with adenosine deaminase enzyme promotes …

…, LC Chew, B Stamp, X Zhang, A Whitt, C Li… - bioRxiv, 2022 - biorxiv.org
Although immune checkpoint inhibitor (ICI) therapy has provided robust results in many
cancer types such as melanoma and lung cancer, a large percentage of patients remain …

[HTML][HTML] Operationalizing a rideshare intervention for colonoscopy completion: barriers, facilitators, and process recommendations

A Bell-Brown, L Chew, BJ Weiner, L Strate… - Frontiers in health …, 2022 - frontiersin.org
Introduction Transportation is a common barrier to colonoscopy completion for colorectal
cancer (CRC) screening. The study aims to identify the barriers, facilitators, and process …

Enzymatic depletion of adenosine to overcome resistance to immune checkpoint inhibitors in non-small cell lung cancer

OS Sarkar, H Donninger, LC Chew, J Eaton… - The Journal of …, 2023 - journals.aai.org
Despite the remarkable outcome of immune checkpoint inhibitors (ICIs) in non-small cell
lung cancer (NSCLC), a large number of patients remain unresponsive to this therapy. A key …

[HTML][HTML] Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

…, LJ Launer, K Leander, RN Lemaitre, CE Lewis… - Nature …, 2019 - nature.com
Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors,
such as physical activity, modify these genetic effects. To identify lipid loci interacting with …

[PDF][PDF] A large-scale multi-ancestry genome-wide study accounting for smoking behavior identifies multiple significant loci for blood pressure

…, C Langenberg, LJ Launer, B Lehne, CE Lewis… - The American Journal of …, 2018 - cell.com
Genome-wide association analysis advanced understanding of blood pressure (BP), a major
risk factor for vascular conditions such as coronary heart disease and stroke. Accounting …

[HTML][HTML] Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries

…, C Langenberg, LJ Launer, B Lehne, CE Lewis… - PloS one, 2018 - journals.plos.org
Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by
which alcohol consumption impact blood pressure (BP) regulation remains unknown. We …

[HTML][HTML] CASPER plus (CollAborative care in Screen-Positive EldeRs with major depressive disorder): study protocol for a randomised controlled trial

…, H Lewis, D Bailey, K Bosanquet, C Chew-Graham… - Trials, 2014 - Springer
… The York based Trial Manager, Helen Lewis, will be responsible for the co-ordination of
the study between the sites. … The process evaluation will be managed by Carolyn Chew-Graham. …

Environmental enrichment slows disease progression in R6/2 Huntington's disease mice

…, A Van Dellen, C Blakemore, CM Lewis… - Annals of Neurology …, 2002 - Wiley Online Library
… They run through it, hide in it, sleep in it, climb over it, stand on it, and chew it up to provide
nesting material. Several mice can play with a tube at any time. Because of the small group …