Stress-inducible MICA, a distant homolog of major histocompatibility complex (MHC) class I,
functions as an antigen for γδ T cells and is frequently expressed in epithelial tumors. A …

Natural killer cells are innate immune cells that control certain microbial infections and tumours.
The function of natural killer cells is regulated by a balance between signals transmitted …

… Although the extracellular domain of human NKG2E is very similar to NKG2C and has a
Lys residue in its transmembrane region, we have been unable to demonstrate that human …

Many immune receptors are composed of separate ligand-binding and signal-transducing
subunits. In natural killer (NK) and T cells, DAP10 was identified as a cell surface adaptor …

The presence and expression of killer inhibitory receptor (KIR) and CD94:NKG2 genes from
68 donors were analyzed using molecular typing techniques. The genes encoding CD94:…

Natural killer (NK) cells are innate immune lymphocytes that express a heterogeneous repertoire
of germline-encoded receptors and undergo a distinct pattern of maturation. CD57 is a …

Neural cell adhesion molecule (N-CAM) is a membrane glycoprotein expressed on neural
and muscle tissues that is involved in homotypic adhesive interactions. We have …

Natural killer (NK) cells were originally defined as effector lymphocytes of innate immunity
endowed with constitutive cytolytic functions. More recently, a more nuanced view of NK cells …

The protein HLA-E is a non-classical major histocompatibility complex (MHC) molecule of
limited sequence variability. Its expression on the cell surface is regulated by the binding of …

▪ Abstract NK cells are regulated by opposing signals from receptors that activate and inhibit
effector function. While positive stimulation may be initiated by an array of co-stimulatory …