The world is currently undergoing a pandemic caused by an H1N1 influenza A virus, the so-called
'swine flu'. The H5N1 ('bird flu') influenza A viruses, now circulating in Asia, Africa and …

Overexpression of proteins in Escherichia coli at low temperature improves their solubility
and stability 1 , 2 . Here, we apply the unique features of the cspA gene to develop a series of …

Influenza A viruses are responsible for seasonal epidemics and high mortality pandemics. A
major function of the viral NS1A protein, a virulence factor, is the inhibition of the production …

The antibacterial peptide microcin J25 (MccJ25) inhibits bacterial transcription by binding
within, and obstructing, the nucleotide-uptake channel of bacterial RNA polymerase. …

Tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) constitute an
important, yet relatively poorly understood, family of heme-containing enzymes. Here, we …

We describe the core Protein Production Platform of the Northeast Structural Genomics
Consortium (NESG) and outline the strategies used for producing high-quality protein samples. …

In this chapter we describe the core Protein Production Platform of the Northeast Structural
Genomics Consortium (NESG) and outline the strategies used for producing high-quality …

Non-structural protein 1 from influenza A virus, NS1A, is a key multifunctional virulence factor
composed of two domains: an N-terminal double-stranded RNA (dsRNA)-binding domain …

Interferon-induced ISG15 conjugation plays an important antiviral role against several viruses,
including influenza viruses. The NS1 protein of influenza B virus (NS1B) specifically binds …

A library of quinoxaline derivatives were prepared to target non-structural protein 1 of
influenza A (NS1A) as a means to develop anti-influenza drug leads. An in vitro fluorescence …