Background: Natural history can be characterized by incidence, recurrence, and duration of
episodes. Research on the incidence of major depression is rare; studies of recurrence and …

Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic
architecture or its genetic relationship with other disorders. To discover loci associated …

Background The field of psychiatric epidemiology continues to employ self-report instruments,
but the low degree of agreement between diagnoses achieved using these instruments vs …

Background Variation in liability to cannabis use disorder has a strong genetic component (estimated
twin and family heritability about 50–70%) and is associated with negative …

OBJECTIVE: The epidemiology of cognitive decline over 11.5 years was investigated in a
large community-residing population, with a special emphasis on the relationship between …

The implementation of pharmacogenomic (PGx) testing in psychiatry remains modest, in
part due to divergent perceptions of the quality and completeness of the evidence base and …

Background: There is an ongoing research effort to test if depression is a homogeneous
clinical syndrome and to identify valid and useful subtypes based on the number and nature of …

Objective: Smoking is highly intractable, and the genetic influences on cessation are unclear.
Identifying the genetic factors affecting smoking cessation could elucidate the nature of …

The mu1 opioid receptor gene, OPRM1, has long been a high-priority candidate for human
genetic studies of addiction. Because of its potential functional significance, the non-…

The American College of Medical Genetics and Genomics (ACMG) recommends that clinical
sequencing laboratories return secondary findings in 56 genes associated with medically …