The use of bacteriophages (phages) for antibacterial therapy is under increasing consideration
to treat antimicrobial-resistant infections. Phages have evolved multiple mechanisms to …

Protein micropatterning enables robust control of cell positioning on electron-microscopy
substrates for cryogenic electron tomography (cryo-ET). However, the combination of regulated …

Cryogenic electron tomography is the highest resolution tool available for structural analysis
of macromolecular organization inside cells. Micropatterning of extracellular matrix (ECM) …

The integrity of epithelia is maintained within dynamic mechanical environments during tissue
development and homeostasis. Understanding how epithelial cells mechanosignal and …

Epithelial cell migration is critical in regulating wound healing and tissue development. The
epithelial microenvironment is incredibly dynamic, subjected to mechanical cues including …

Controlling cellular shape with protein micropatterning can mimic physiological morphologies
and has been shown to improve reproducibility, enhancing our ability to collect statistics …

Yes Associated Protein (YAP) is a mechanosensitive transcriptional activator regulating a
variety of cell fates, including proliferation and cell growth. YAP is activated (localized to the …

We designed and fabricated, using low-cost 3D printing technologies, a device that enables
direct control of cell density in epithelial monolayers. The device operates by varying the …

Heart disease is the leading cause of death in the US, and human cell models are needed
to study how structure and function are related in heart health and disease. Human induced …

Active materials are a collection of self-driven units that independently operate to give a
material unique, large-scale, global properties (eg, flock of birds). Mammalian epithelia, which …