Neurexins (NXs) and neuroligins (NLs) are transsynaptically interacting cell adhesion
proteins that play a key role in the formation, maturation, activity-dependent validation, and …

Excitotoxicity after glutamate receptor overactivation induces disturbances in cellular ion
gradients, resulting in necrosis or apoptosis. Excitotoxic necrosis is triggered by rapid, …

Neuroligins are postsynaptic adhesion proteins involved in the establishment of functional
synapses in the central nervous system. In rodents, four genes give rise to neuroligins that …

10.7554/eLife.22466.001 Beyond its role in parturition and lactation, oxytocin influences
higher brain processes that control social behavior of mammals, and perturbed oxytocin …

Excitotoxicity resulting from excessive Ca 2+ influx through glutamate receptors contributes
to neuronal injury after stroke, trauma, and seizures. Increased cytosolic Ca 2+ levels …

5′-Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a key sensor of
cellular energy status. AMPK signaling regulates energy balance at the cellular, organ, and …

X-linked inhibitor of apoptosis protein (XIAP) is a potent inhibitor of caspases 3, 7 and 9,
and mitochondrial Smac (second mitochondria-derived activator of caspase) release during …

Disturbance of homeostasis within the endoplasmic reticulum ( ER ) lumen leads to the
accumulation of unfolded and misfolded proteins. This results in the activation of an evolutionary …

Disruption of endoplasmic reticulum (ER) Ca 2+ homeostasis and ER dysfunction have been
suggested to contribute to excitotoxic and ischaemic neuronal injury. Previously, we have …

Proteasomal stress and the accumulation of polyubiquitinated proteins are key features of
numerous neurodegenerative disorders. Previously we demonstrated that stabilization of p53 …