User profiles for Liam Sharp
 | Liam SharpRutgers University Camden Verified email at scarletmail.rutgers.edu Cited by 98 |
[HTML][HTML] Anionic phospholipids control mechanisms of GPCR-G protein recognition
G protein-coupled receptors (GPCRs) are embedded in phospholipids that strongly influence
drug-stimulated signaling. Anionic lipids are particularly important for GPCR signaling …
drug-stimulated signaling. Anionic lipids are particularly important for GPCR signaling …
Direct binding of phosphatidylglycerol at specific sites modulates desensitization of a ligand-gated ion channel
10.7554/eLife.50766.001 Pentameric ligand-gated ion channels (pLGICs) are essential
determinants of synaptic transmission, and are modulated by specific lipids including anionic …
determinants of synaptic transmission, and are modulated by specific lipids including anionic …
[HTML][HTML] Spontaneous lipid binding to the nicotinic acetylcholine receptor in a native membrane
L Sharp, G Brannigan - The Journal of Chemical Physics, 2021 - pubs.aip.org
The nicotinic acetylcholine receptor (nAChR) and other pentameric ligand-gated ion channels
are native to neuronal membranes with an unusual lipid composition. While it is well-…
are native to neuronal membranes with an unusual lipid composition. While it is well-…
A cross‐sectional, observational study of nutritional status and eating behaviours in people living with dementia in acute care settings
…, C Ataiza, MH Ho, YY Chung, L Sharp… - Journal of Clinical …, 2023 - Wiley Online Library
Aims and Objectives To understand the nutritional status, observing eating difficulties during
mealtimes for people living with dementia in acute care settings. Background Changed …
mealtimes for people living with dementia in acute care settings. Background Changed …
[HTML][HTML] Boundary lipids of the nicotinic acetylcholine receptor: Spontaneous partitioning via coarse-grained molecular dynamics simulation
Reconstituted nicotinic acetylcholine receptors (nAChRs) exhibit significant gain-of-function
upon addition of cholesterol to reconstitution mixtures, and cholesterol affects the …
upon addition of cholesterol to reconstitution mixtures, and cholesterol affects the …
Knowledge of and attitudes toward assisting patients with dementia during mealtime among nursing staff in acute care settings: A cross-sectional study
C Ataiza, MH Ho, L Sharp, MF Liu, CC Chang… - Collegian, 2022 - Elsevier
Background Mealtime difficulties are exacerbated in acute care settings, which further
complicate health issues in people with dementia (PWD). Understanding staff knowledge and …
complicate health issues in people with dementia (PWD). Understanding staff knowledge and …
Untangling direct and domain-mediated interactions between nicotinic acetylcholine receptors in DHA-rich membranes
K Woods, L Sharp, G Brannigan - The Journal of membrane biology, 2019 - Springer
At the neuromuscular junction (NMJ), the nicotinic acetylcholine receptor (nAChR) self-associates
to give rise to rapid muscle movement. While lipid domains have maintained nAChR …
to give rise to rapid muscle movement. While lipid domains have maintained nAChR …
Varying the position of phospholipid acyl chain unsaturation modulates hopanoid and sterol ordering
The cell membrane acts as a responsive interface between the cell and its surroundings.
Ultimately, the diverse panel of lipids comprising the lipidome are employed to tune membrane …
Ultimately, the diverse panel of lipids comprising the lipidome are employed to tune membrane …
Direct binding of phosphatidylglycerol at specific sites modulates desensitization of a pentameric ligand-gated ion channel
Pentameric ligand-gated ion channels (pLGICs) are essential determinants of synaptic
transmission, and are modulated by specific lipids including anionic phospholipids. The exact …
transmission, and are modulated by specific lipids including anionic phospholipids. The exact …
Phosphatidyl serine preconditions the A2AAR for G-protein coupling via a conserved motif on TM6 and TM7
510a Wednesday, February 22, 2023 headgroups, but without the G-protein. Consistent with
our hypothesis, the TM6–TM7 interactions are similar to the G-protein coupled state in the …
our hypothesis, the TM6–TM7 interactions are similar to the G-protein coupled state in the …