Understanding the origins and roles of cardiac progenitor cells is important for elucidating
the pathogenesis of congenital and acquired heart diseases 1 , 2 . Moreover, manipulation of …

We deleted the hypoxia-responsive transcription factor HIF-1α in endothelial cells (EC) to
determine its role during neovascularization. We found that loss of HIF-1α inhibits a number of …

Here we have studied the involvement of endothelial heparan sulfate in inflammation by
inactivating the enzyme N-acetyl glucosamine N-deacetylase–N-sulfotransferase-1 in …

The epicardium makes essential cellular and paracrine contributions to the growth of the
fetal myocardium and the formation of the coronary vasculature. However, whether the …

Heparin has been used clinically as an anticoagulant and antithrombotic agent for over 60
years. Here we show that the potent anti-inflammatory property of heparin results primarily …

Delivery of nanoparticle drugs to tumors relies heavily on the enhanced permeability and
retention (EPR) effect. While many consider the effect to be equally effective on all tumors, it …

Heparin is an excellent inhibitor of P- and L-selectin binding to the carbohydrate determinant,
sialyl Lewis x . As a consequence of its anti-selectin activity, heparin attenuates metastasis …

We examined the role of hepatic heparan sulfate in triglyceride-rich lipoprotein metabolism
by inactivating the biosynthetic gene GlcNAc N-deacetylase/N-sulfotransferase 1 (Ndst1) in …

To facilitate qualitative and quantitative analysis of glycosaminoglycans, we tagged the
reducing end of lyase-generated disaccharides with aniline-containing stable isotopes ( 12 C 6 …

Conventional photodynamic therapy (PDT)'s clinical application is limited by depth of
penetration by light. To address the issue, we have recently developed X-ray induced …