Alzheimer's disease (AD) is the most common cause of dementia, affecting 35 million people
worldwide. One pathological feature of progressing AD is the loss of synapses. This is the …

There is growing evidence that mechanical factors affect brain functioning. However, brain
components responsible for regulating the physiological mechanical environment are not …

Peripheral nervous system ( PNS ) neurons support axon regeneration into adulthood, whereas
central nervous system ( CNS ) neurons lose regenerative ability after development. To …

Alzheimer's disease (AD) is the most common cause of dementia. Despite many years of
research, very limited treatment options are available. Here we aim to establish a well-defined …

Alzheimer pathology is accompanied by astrogliosis. Reactive astrocytes surrounding
amyloid plaques may directly affect neuronal communication, and one of the mechanisms by …

Dysregulation of microglial function contributes to Alzheimer’s disease (AD) pathogenesis.
Several genetic and transcriptome studies have revealed microglia specific genetic risk …

There is increasing evidence of altered tissue mechanics in neurodegeneration. However,
due to difficulties in mechanical testing procedures and the complexity of the brain, there is …

Peripheral nervous system (PNS) neurons support axon regeneration into adulthood, whereas
central nervous system (CNS) neurons lose regenerative ability after development. To …

Background Emerging evidence suggests that peripheral immunity plays an important role
in the progression of Alzheimer’s disease (AD) (Gate et al., 2020). However, more …

Aging coincides with major changes in brain immunity that aid in a decline in neuronal function.
Here, we postulate that systemic, pro-aging factors contribute to immunological changes …