[HTML][HTML] Genetic structure of Europeans: a view from the North–East
Using principal component (PC) analysis, we studied the genetic constitution of 3,112
individuals from Europe as portrayed by more than 270,000 single nucleotide polymorphisms (…
individuals from Europe as portrayed by more than 270,000 single nucleotide polymorphisms (…
[HTML][HTML] Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants
…, D Niederacher, FC Nielsen, L Nikitina-Zake… - Genetics in …, 2020 - nature.com
Purpose We assessed the associations between population-based polygenic risk scores (PRS)
for breast (BC) or epithelial ovarian cancer (EOC) with cancer risks for BRCA1 and …
for breast (BC) or epithelial ovarian cancer (EOC) with cancer risks for BRCA1 and …
Association of genetic variation in the organic cation transporters OCT1, OCT2 and multidrug and toxin extrusion 1 transporter protein genes with the gastrointestinal …
…, R Ritenberga, L Nikitina-Zake… - Pharmacogenetics …, 2012 - journals.lww.com
Objective Metformin is the most widely used oral antidiabetic drug for the treatment of type 2
diabetes (T2D). So far, the number of polymorphisms in SLC22A1, SLC22A2, and SLC47A1 …
diabetes (T2D). So far, the number of polymorphisms in SLC22A1, SLC22A2, and SLC47A1 …
[HTML][HTML] Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer
…, I Nevelsteen, FC Nielsen, L Nikitina-Zake… - Nature …, 2019 - nature.com
Genome-wide association studies (GWAS) have identified more than 170 breast cancer
susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-…
susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-…
Genome Database of the Latvian Population (LGDB): design, goals, and primary results
…, Y Wolff-Sagi, L Zaharenko, L Nikitina-Zake… - Journal of …, 2018 - jstage.jst.go.jp
Background: The Genome Database of the Latvian Population (LGDB) is a national biobank
that collects, maintains, and processes health information, data, and biospecimens …
that collects, maintains, and processes health information, data, and biospecimens …
Characterization of the cancer spectrum in men with germline BRCA1 and BRCA2 pathogenic variants: results from the consortium of investigators of modifiers of …
…, H Nevanlinna, J Ngeow, L Nikitina-Zake… - JAMA …, 2020 - jamanetwork.com
Importance The limited data on cancer phenotypes in men with germlineBRCA1 and
BRCA2pathogenic variants (PVs) have hampered the development of evidence-based …
BRCA2pathogenic variants (PVs) have hampered the development of evidence-based …
[HTML][HTML] Genetic characterization of northeastern Italian population isolates in the context of broader European genetic diversity
…, K Rehnström, M Traglia, L Nikitina-Zake… - European Journal of …, 2013 - nature.com
Population genetic studies on European populations have highlighted Italy as one of genetically
most diverse regions. This is possibly due to the country’s complex demographic history …
most diverse regions. This is possibly due to the country’s complex demographic history …
A transcriptome-wide association study among 97,898 women to identify candidate susceptibility genes for epithelial ovarian cancer risk
…, H Nevanlinna, FC Nielsen, L Nikitina-Zake… - Cancer research, 2018 - AACR
Large-scale genome-wide association studies (GWAS) have identified approximately 35
loci associated with epithelial ovarian cancer (EOC) risk. The majority of GWAS-identified …
loci associated with epithelial ovarian cancer (EOC) risk. The majority of GWAS-identified …
Identification of glyoxalase 1 polymorphisms associated with enzyme activity
…, I Konrade, E Skapare, D Fridmanis, L Nikitina-Zake… - Gene, 2013 - Elsevier
The glyoxalase system and its main enzyme, glyoxalase 1 (GLO1), protect cells from
advanced glycation end products (AGEs), such as methylglyoxal (MG) and other reactive …
advanced glycation end products (AGEs), such as methylglyoxal (MG) and other reactive …
[HTML][HTML] Ovarian cancer pathology characteristics as predictors of variant pathogenicity in BRCA1 and BRCA2
…, PA James, R Janavicius, L Nikitina-Zake… - British journal of …, 2023 - nature.com
Background The distribution of ovarian tumour characteristics differs between germline BRCA1
and BRCA2 pathogenic variant carriers and non-carriers. In this study, we assessed the …
and BRCA2 pathogenic variant carriers and non-carriers. In this study, we assessed the …