Unpacking the gateway hypothesis of e-cigarette use: the need for triangulation of individual-and population-level data

L Shahab, J Brown, L Boelen, E Beard… - Nicotine and …, 2022 - academic.oup.com
As recent publications in N&TR highlight, 1 there is considerable debate whether e-cigarettes
act as a causal gateway to subsequent smoking in adolescents. Answering this question …

The fate and lifespan of human monocyte subsets in steady state and systemic inflammation

AA Patel, Y Zhang, JN Fullerton, L Boelen… - Journal of Experimental …, 2017 - rupress.org
In humans, the monocyte pool comprises three subsets (classical, intermediate, and
nonclassical) that circulate in dynamic equilibrium. The kinetics underlying their generation, …

[PDF][PDF] Human stem cell-like memory T cells are maintained in a state of dynamic flux

…, L Roger, PC Del Amo, KL Miners, RE Jones, L Boelen… - Cell reports, 2016 - cell.com
Adaptive immunity requires the generation of memory T cells from naive precursors selected
in the thymus. The key intermediaries in this process are stem cell-like memory T (T SCM ) …

Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia

…, S Foster, D Goode, WK Lim, L Boelen… - Blood, The Journal …, 2013 - ashpublications.org
Aberrant transcriptional programs in combination with abnormal proliferative signaling drive
leukemic transformation. These programs operate in normal hematopoiesis where they are …

[HTML][HTML] Human TSCM cell dynamics in vivo are compatible with long-lived immunological memory and stemness

P Costa Del Amo, J Lahoz-Beneytez, L Boelen… - PLoS …, 2018 - journals.plos.org
Adaptive immunity relies on the generation and maintenance of memory T cells to provide
protection against repeated antigen exposure. It has been hypothesised that a self-renewing …

PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells

…, P Zarzour, D Beck, L Boelen… - Proceedings of the …, 2016 - National Acad Sciences
Current approaches in tissue engineering are geared toward generating tissue-specific stem
cells. Given the complexity and heterogeneity of tissues, this approach has its limitations. …

[HTML][HTML] Transmission of hepatitis C virus among prisoners, Australia, 2005–2012

NA Bretaña, L Boelen, R Bull, S Teutsch… - Emerging infectious …, 2015 - ncbi.nlm.nih.gov
Hepatitis C virus (HCV) is predominantly transmitted between persons who inject drugs. For
this population, global prevalence of HCV infection is high and incarceration is common and …

A Bayesian cluster analysis method for single-molecule localization microscopy data

J Griffié, M Shannon, CL Bromley, L Boelen, GL Burn… - Nature …, 2016 - nature.com
Cell function is regulated by the spatiotemporal organization of the signaling machinery,
and a key facet of this is molecular clustering. Here, we present a protocol for the analysis of …

Inhibitory killer cell immunoglobulin-like receptors strengthen CD8+ T cell–mediated control of HIV-1, HCV, and HTLV-1

L Boelen, B Debebe, M Silveira, A Salam… - Science …, 2018 - science.org
Killer cell immunoglobulin-like receptors (KIRs) are expressed predominantly on natural
killer cells, where they play a key role in the regulation of innate immune responses. Recent …

Discrete Painlevé equations for recurrence coefficients of semiclassical Laguerre polynomials

L Boelen, W Van Assche - Proceedings of the American Mathematical …, 2010 - ams.org
We consider two semiclassical extensions of the Laguerre weight and their associated sets
of orthogonal polynomials. These polynomials satisfy a three-term recurrence relation. We …