Unpacking the gateway hypothesis of e-cigarette use: the need for triangulation of individual-and population-level data
As recent publications in N&TR highlight, 1 there is considerable debate whether e-cigarettes
act as a causal gateway to subsequent smoking in adolescents. Answering this question …
act as a causal gateway to subsequent smoking in adolescents. Answering this question …
The fate and lifespan of human monocyte subsets in steady state and systemic inflammation
AA Patel, Y Zhang, JN Fullerton, L Boelen… - Journal of Experimental …, 2017 - rupress.org
In humans, the monocyte pool comprises three subsets (classical, intermediate, and
nonclassical) that circulate in dynamic equilibrium. The kinetics underlying their generation, …
nonclassical) that circulate in dynamic equilibrium. The kinetics underlying their generation, …
[PDF][PDF] Human stem cell-like memory T cells are maintained in a state of dynamic flux
…, L Roger, PC Del Amo, KL Miners, RE Jones, L Boelen… - Cell reports, 2016 - cell.com
Adaptive immunity requires the generation of memory T cells from naive precursors selected
in the thymus. The key intermediaries in this process are stem cell-like memory T (T SCM ) …
in the thymus. The key intermediaries in this process are stem cell-like memory T (T SCM ) …
Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia
Aberrant transcriptional programs in combination with abnormal proliferative signaling drive
leukemic transformation. These programs operate in normal hematopoiesis where they are …
leukemic transformation. These programs operate in normal hematopoiesis where they are …
[HTML][HTML] Human TSCM cell dynamics in vivo are compatible with long-lived immunological memory and stemness
P Costa Del Amo, J Lahoz-Beneytez, L Boelen… - PLoS …, 2018 - journals.plos.org
Adaptive immunity relies on the generation and maintenance of memory T cells to provide
protection against repeated antigen exposure. It has been hypothesised that a self-renewing …
protection against repeated antigen exposure. It has been hypothesised that a self-renewing …
PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells
…, P Zarzour, D Beck, L Boelen… - Proceedings of the …, 2016 - National Acad Sciences
Current approaches in tissue engineering are geared toward generating tissue-specific stem
cells. Given the complexity and heterogeneity of tissues, this approach has its limitations. …
cells. Given the complexity and heterogeneity of tissues, this approach has its limitations. …
[HTML][HTML] Transmission of hepatitis C virus among prisoners, Australia, 2005–2012
NA Bretaña, L Boelen, R Bull, S Teutsch… - Emerging infectious …, 2015 - ncbi.nlm.nih.gov
Hepatitis C virus (HCV) is predominantly transmitted between persons who inject drugs. For
this population, global prevalence of HCV infection is high and incarceration is common and …
this population, global prevalence of HCV infection is high and incarceration is common and …
A Bayesian cluster analysis method for single-molecule localization microscopy data
Cell function is regulated by the spatiotemporal organization of the signaling machinery,
and a key facet of this is molecular clustering. Here, we present a protocol for the analysis of …
and a key facet of this is molecular clustering. Here, we present a protocol for the analysis of …
Inhibitory killer cell immunoglobulin-like receptors strengthen CD8+ T cell–mediated control of HIV-1, HCV, and HTLV-1
L Boelen, B Debebe, M Silveira, A Salam… - Science …, 2018 - science.org
Killer cell immunoglobulin-like receptors (KIRs) are expressed predominantly on natural
killer cells, where they play a key role in the regulation of innate immune responses. Recent …
killer cells, where they play a key role in the regulation of innate immune responses. Recent …
Discrete Painlevé equations for recurrence coefficients of semiclassical Laguerre polynomials
L Boelen, W Van Assche - Proceedings of the American Mathematical …, 2010 - ams.org
We consider two semiclassical extensions of the Laguerre weight and their associated sets
of orthogonal polynomials. These polynomials satisfy a three-term recurrence relation. We …
of orthogonal polynomials. These polynomials satisfy a three-term recurrence relation. We …