A plethora of apoptotic stimuli converge on the mitochondria and affect their membrane
integrity. As a consequence, multiple death-promoting factors residing in the mitochondrial …

The HtrA family refers to a group of related oligomeric serine proteases that combine a
trypsin-like protease domain with at least one PDZ interaction domain. Mammals encode four …

Inflammasomes are macromolecular complexes formed in response to pathogen‐associated
molecular patterns (PAMPs) and danger‐associated molecular patterns (DAMPs) that drive …

Autophagy and apoptosis are two important and interconnected stress-response mechanisms.
However, the molecular interplay between these two pathways is not fully understood. To …

Endotoxin administration recapitulates many of the host responses to sepsis. Inhibitors of the
cysteine protease caspase 1 have long been sought as a therapeutic because mice lacking …

The Nlrp3 inflammasome is critical for host immunity, but the mechanisms controlling its
activation are enigmatic. In this study, we show that loss of FADD or caspase-8 in a RIP3-…

Rheumatoid arthritis is a chronic autoinflammatory disease that affects 1–2% of the world’s
population and is characterized by widespread joint inflammation. Interleukin-1 is an …

Caspase-1 activation by inflammasome scaffolds comprised of intracellular nucleotide-binding
oligomerization domain (NOD)-like receptors (NLRs) and the adaptor ASC is believed to …

During endoplasmic reticulum (ER) stress, homeostatic signaling through the unfolded protein
response (UPR) augments ER protein-folding capacity. If homeostasis is not restored, the …

Injury and physical trauma may inflict accidental cell death, but we have come to realize during
the past four decades that cells may also actively engage cell death when needed. These …