User profiles for Lieven Clement

Lieven Clement

Associate Professor in Statistical Genomics, Ghent University
Verified email at ugent.be
Cited by 4249

RNA sequencing data: hitchhiker's guide to expression analysis

…, C Soneson, S Tiberi, L Clement… - Annual Review of …, 2019 - annualreviews.org
Gene expression is the fundamental level at which the results of various genetic and regulatory
programs are observable. The measurement of transcriptome-wide gene expression has …

Initial community evenness favours functionality under selective stress

L Wittebolle, M Marzorati, L Clement, A Balloi… - Nature, 2009 - nature.com
Owing to the present global biodiversity crisis, the biodiversity–stability relationship and the
effect of biodiversity on ecosystem functioning have become major topics in ecology 1 , 2 , 3 . …

Experimental design and data-analysis in label-free quantitative LC/MS proteomics: A tutorial with MSqRob

LJE Goeminne, K Gevaert, L Clement - Journal of proteomics, 2018 - Elsevier
Label-free shotgun proteomics is routinely used to assess proteomes. However, extracting
relevant information from the massive amounts of generated data remains difficult. This …

[HTML][HTML] Trajectory-based differential expression analysis for single-cell sequencing data

…, R Cannoodt, Y Saeys, S Dudoit, L Clement - Nature …, 2020 - nature.com
Trajectory inference has radically enhanced single-cell RNA-seq research by enabling the
study of dynamic changes in gene expression. Downstream of trajectory inference, it is vital to …

Leaf responses to mild drought stress in natural variants of Arabidopsis

…, T Van Daele, K Maleux, V Storme, L Clement… - Plant …, 2015 - academic.oup.com
Although the response of plants exposed to severe drought stress has been studied extensively,
little is known about how plants adapt their growth under mild drought stress conditions. …

Identification of novel causative genes determining the complex trait of high ethanol tolerance in yeast using pooled-segregant whole-genome sequence analysis

…, A Goovaerts, K Souvereyns, L Clement… - Genome …, 2012 - genome.cshlp.org
High ethanol tolerance is an exquisite characteristic of the yeast Saccharomyces cerevisiae,
which enables this microorganism to dominate in natural and industrial fermentations. Up to …

[HTML][HTML] Observation weights unlock bulk RNA-seq tools for zero inflation and single-cell applications

…, D Risso, JP Vert, MD Robinson, S Dudoit, L Clement - Genome biology, 2018 - Springer
Dropout events in single-cell RNA sequencing (scRNA-seq) cause many transcripts to go
undetected and induce an excess of zero read counts, leading to power issues in differential …

Measuring the biodiversity of microbial communities by flow cytometry

…, P Monsieurs, M Mysara, L Clement… - Methods in Ecology …, 2016 - Wiley Online Library
Measuring the microbial diversity in natural and engineered environments is important for
ecosystem characterization, ecosystem monitoring and hypothesis testing. Although the …

Flow cytometry for fast microbial community fingerprinting

K De Roy, L Clement, O Thas, Y Wang, N Boon - water research, 2012 - Elsevier
Characterizing the microbial community of water is important in different domains, ranging
from food and beverage production to wastewater treatment. Conventional methods, such as …

Probabilistic index models

O Thas, JD Neve, L Clement… - Journal of the Royal …, 2012 - academic.oup.com
We present a semiparametric statistical model for the probabilistic index which can be defined
as P(Y⩽Y * ), where Y and Y * are independent random response variables associated …