User profiles for Lilia Kaustov
Lilia KaustovSunnybrook Health Sciences Centre Verified email at sunnybrook.ca Cited by 1769 |
[HTML][HTML] Recognition and specificity determinants of the human cbx chromodomains
L Kaustov, H Ouyang, M Amaya, A Lemak… - Journal of Biological …, 2011 - ASBMB
The eight mammalian Cbx proteins are chromodomain-containing proteins involved in
regulation of heterochromatin, gene expression, and developmental programs. They are …
regulation of heterochromatin, gene expression, and developmental programs. They are …
Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A
E Bochkareva, L Kaustov, A Ayed… - Proceedings of the …, 2005 - National Acad Sciences
One of many protein–protein interactions modulated upon DNA damage is that of the single-stranded
DNA-binding protein, replication protein A (RPA), with the p53 tumor suppressor. …
DNA-binding protein, replication protein A (RPA), with the p53 tumor suppressor. …
[PDF][PDF] Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks
…, Y Ichijima, A Fradet-Turcotte, CCY Leung, L Kaustov… - Molecular cell, 2012 - cell.com
The response to DNA double-strand breaks (DSBs) entails the hierarchical recruitment of
proteins orchestrated by ATM-dependent phosphorylation and RNF8-mediated chromatin …
proteins orchestrated by ATM-dependent phosphorylation and RNF8-mediated chromatin …
Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1
…, F Yan, BM Dickson, AH Guo, DV Cantu, L Kaustov… - Elife, 2016 - elifesciences.org
10.7554/eLife.17101.001 The epigenetic inheritance of DNA methylation requires UHRF1,
a histone- and DNA-binding RING E3 ubiquitin ligase that recruits DNMT1 to sites of newly …
a histone- and DNA-binding RING E3 ubiquitin ligase that recruits DNMT1 to sites of newly …
[HTML][HTML] Cognitive deficits after general anaesthesia in animal models: a scoping review
LY Guo, L Kaustov, CTA Brenna, V Patel… - British Journal of …, 2023 - Elsevier
Background It remains controversial whether general anaesthetic drugs contribute to
perioperative neurocognitive disorders in adult patients. Preclinical studies have generated …
perioperative neurocognitive disorders in adult patients. Preclinical studies have generated …
[PDF][PDF] Cbx2 targets PRC1 to constitutive heterochromatin in mouse zygotes in a parent-of-origin-dependent manner
Polycomb repressive complexes PRC1 and PRC2 regulate expression of genes involved in
proliferation and development. In mouse early embryos, however, canonical PRC1 localizes …
proliferation and development. In mouse early embryos, however, canonical PRC1 localizes …
[HTML][HTML] Role of Pirh2 in mediating the regulation of p53 and c-Myc
Ubiquitylation is fundamental for the regulation of the stability and function of p53 and c-Myc.
The E3 ligase Pirh2 has been reported to polyubiquitylate p53 and to mediate its …
The E3 ligase Pirh2 has been reported to polyubiquitylate p53 and to mediate its …
[HTML][HTML] Creating a Successful Virtual Reality–Based Medical Simulation Environment: Tutorial
Innovation in medical education is not only inevitable but a requirement. Manikin-based
simulation is currently the gold standard for supplemental clinical training; however, this …
simulation is currently the gold standard for supplemental clinical training; however, this …
The Effects of dexmedetomidine on perioperative neurocognitive outcomes after cardiac surgery: a systematic review and meta-analysis of randomized controlled …
A Singh, CTA Brenna, J Broad, L Kaustov… - Annals of surgery, 2022 - journals.lww.com
Objective: The purpose of this systematic review and meta-analysis is to examine the effect
of DEX on delayed dNCR (cognitive dysfunction≥ 1 week postoperative) after cardiac …
of DEX on delayed dNCR (cognitive dysfunction≥ 1 week postoperative) after cardiac …
[HTML][HTML] Comparison of the effects of perineural or intravenous dexamethasone on low volume interscalene brachial plexus block: a randomised equivalence trial
…, B Safa, PDG Henry, A Kiss, SK Au, L Kaustov… - British journal of …, 2020 - Elsevier
Background Efforts to prolong interscalene block (ISB) analgesia include the use of local
anaesthetic adjuvants such as dexamethasone. Previous work showing prolonged block …
anaesthetic adjuvants such as dexamethasone. Previous work showing prolonged block …