The HECT domain E3 ligase HACE1 has been identified as a tumor suppressor in multiple
cancers. Here, we report that HACE1 is a central gatekeeper of TNFR1-induced cell fate. …

Ubiquitin modification (ubiquitination) of target proteins can vary with respect to chain lengths,
linkage type, and chain forms, such as homologous, mixed, and branched ubiquitin chains…

HOIP, the catalytic component of the linear ubiquitin chain assembly complex (LUBAC), is a
critical regulator of inflammation. However, how HOIP itself is regulated to control …

In the mammalian species studied so far, the l-histidine decarboxylase (HDC) enzyme
responsible for histamine biosynthesis has been shown to undergo post-translational processing. …

The Linear Ubiquitin Chain Assembly Complex (LUBAC), composed of HOIP, HOIL-1L, and
SHARPIN, promotes tumor necrosis factor (TNF)-dependent NF-κB signaling in diverse cell …

HOIP, the catalytic component of the Linear Ubiquitin chain Assembly Complex (LUBAC), is
a critical regulator of inflammation. However, how HOIP itself is regulated to control …

… to 218.7 g and LVM/Ht 70.2 g/m, 25.9 to 119.8 g/m for age and sex matched controls; P < …
transplant recipient's LVM/Ht (51.2 g/m) was twice that of the appropriate control (25.9 g/m). …

Background Pseudomonas aeruginosa is a persistent and difficult-to-treat pathogen in
many patients, especially those with Cystic Fibrosis (CF). Herein, we describe a longitudinal …

Dairy cow milk is both economically and nutritionally important to humans. Diet has been
termed as the main driving force toward differences in milk production and composition. The …

Purpose Genetic variants causing aberrant premessenger RNA splicing are increasingly
being recognized as causal variants in genetic disorders. In this study, we devise standardized …