A key aspect of nearly all single-cell sequencing experiments is dissociation of intact tissues
into single-cell suspensions. While many protocols have been optimized for optimal cell …

Immunotherapies targeting the immune checkpoint receptor programmed cell death protein
1 (PD-1) have shown remarkable efficacy in treating cancer. CD4+ CD25 hi FoxP3+ Tregs …

Regulatory T (T reg ) cells constitute a dynamic population that is essential for controlling
immune responses in health and disease. Defects in T reg cell function and decreases in T reg …

CD137 (4-1BB)-activating receptor represents a promising cancer immunotherapeutic target.
Yet, the cellular program driven by CD137 and its role in cancer immune surveillance …

Th1 Tregs are characterized by the acquisition of proinflammatory cytokine secretion and
reduced suppressor activity. Th1 Tregs are found at increased frequency in autoimmune …

Understanding the relationship between tumor and peripheral immune environments could
allow longitudinal immune monitoring in cancer. Here, we examined whether T cells that …

Immune checkpoint blockade has demonstrated success in treating cancer but can lead to
immune-related adverse events (irAEs), illustrating the centrality of these pathways in …

Genome-wide association studies identifying hundreds of susceptibility loci for autoimmune
diseases indicate that genes active in immune cells predominantly mediate risk. However, …

The T cell receptor (TCR) endows T cells with antigen specificity and is central to nearly all
aspects of T cell function. Each naïve T cell has a unique TCR sequence that is stably …

Objective To identify coinhibitory immune pathways important in the brain, we hypothesized
that comparison of T cells in lesions from patients with MS with tumor-infiltrating T cells (TILs) …