A 2.91-billion base pair (bp) consensus sequence of the euchromatic portion of the human
genome was generated by the whole-genome shotgun sequencing method. The 14.8-billion …

Salmonella enterica subspecies I, serovar Typhimurium (S. typhimurium), is a leading cause
of human gastroenteritis, and is used as a mouse model of human typhoid fever 1 . The …

Background The genome of the domestic cow, Bos taurus, was sequenced using a mixture
of hierarchical and whole-genome shotgun sequencing methods. Results We have …

We address the problem of efficiently aligning a transcribed and spliced DNA sequence with
a genomic sequence containing that gene, allowing for introns in the genomic sequence …

Salmonella enterica serovars often have a broad host range, and some cause both
gastrointestinal and systemic disease. But the serovars Paratyphi A and Typhi are restricted to …

A synergistic combination of two next-generation sequencing platforms with a detailed
comparative BAC physical contig map provided a cost-effective assembly of the genome …

Alternative splicing is widely recognized for its roles in regulating genes and creating gene
diversity. However, despite many efforts, the repertoire of gene splicing variation is still …

Background Next-generation sequencing of cellular RNA (RNA-seq) is rapidly becoming
the cornerstone of transcriptomic analysis. However, sequencing errors in the already short …

Lighter is a fast, memory-efficient tool for correcting sequencing errors. Lighter avoids
counting k-mers. Instead, it uses a pair of Bloom filters, one holding a sample of the input k-mers …

We report a whole-genome shotgun assembly (called WGSA) of the human genome
generated at Celera in 2001. The Celera-generated shotgun data set consisted of 27 million …