Selective autophagy of damaged mitochondria requires autophagy receptors optineurin (OPTN),
NDP52 (CALCOCO2), TAX1BP1, and p62 (SQSTM1) linking ubiquitinated cargo to …

Ubiquitylation is among the most prevalent post‐translational modifications ( PTM s) and
regulates numerous cellular functions. Interestingly, ubiquitin (Ub) can be itself modified by …

Ubiquitination of invading Salmonella Typhimurium triggers autophagy of cytosolic bacteria
and restricts their spread in epithelial cells. Ubiquitin (Ub) chains recruit autophagy receptors …

SMAD transcription factors are key intracellular transducers of TGFβ cytokines. SMADs are
tightly regulated to ensure balanced cellular responses to TGFβ signals. Ubiquitylation has a …

The TGFβ receptors signal through phosphorylation and nuclear translocation of SMAD2/3.
SMAD7, a transcriptional target of TGFβ signals, negatively regulates the TGFβ pathway by …

Autophagy is a highly conserved catabolic process through which defective or otherwise
harmful cellular components are targeted for degradation via the lysosomal route. Regulatory …

We developed a pharmacophore model for type II inhibitors that was used to guide the
construction of a library of kinase inhibitors. Kinome-wide selectivity profiling of the library …

The hallmark of Salmonella Typhimurium infection is an acute intestinal inflammatory
response, which is mediated through the action of secreted bacterial effector proteins. The pro-…

The deubiquitylating enzyme OTUB1 is present in all tissues and targets many substrates, in
both the cytosol and nucleus. We found that casein kinase 2 (CK2) phosphorylated OTUB1 …

TANK-binding kinase 1 (TBK1) is a druggable multifunctional kinase that exerts a broad
spectrum of functions in cells. These range from innate immunity, inflammation and interferon (…