Aims To establish pre-clinical proof of concept that sustained subcutaneous delivery of the
secretome of human cardiac stem cells (CSCs) can be achieved in vivo to produce significant …

Cytotoxic T-cells are the major mediators of β-cell destruction in type 1 diabetes, but the
molecular mechanisms are not definitively established. We have examined the contribution of …

Direct interaction between auto-reactive CTL and specific peptide–MHC class I complexes
on pancreatic beta cells is critical in mediating beta cell destruction in type I diabetes. We …

T cells specific for proinsulin and islet-specific glucose-6-phosphatase catalytic subunit related
protein (IGRP) induce diabetes in nonobese diabetic (NOD) mice. TCR transgenic mice …

TNF has been implicated in the pathogenesis of type 1 diabetes. When administered early
in life, TNF accelerates and increases diabetes in NOD mice. However, when administered …

Type 1 diabetes (T1D) is an autoimmune disease that selectively destroys insulin-producing
β-cells in the pancreas. An unmet need in diabetes management, current therapy is …

We present a case of an obese 22-year-old man with activating GCK variant who had
neonatal hypoglycemia, re-emerging with hypoglycemia later in life. We investigated him for …

Human islets are subjected to a number of stresses before and during their isolation that
may influence their survival and engraftment after transplantation. Apoptosis is likely to be …

Type 1, or autoimmune, diabetes is caused by the T-cell mediated destruction of the insulin-producing
pancreatic beta cells. Non-obese diabetic (NOD) mice spontaneously develop …

β-cells are a type of endocrine cell found in pancreatic islets that synthesize, store and
release insulin. In type 1 diabetes (T1D), T-cells of the immune system selectively destroy the …