Argonaute (AGO) proteins associate with small RNAs to direct their effector function on
complementary transcripts. The nematode Caenorhabditis elegans contains an expanded family …

Microsporidia are obligate intracellular parasites that can infect a wide range of hosts. They
cause death and disease in both humans and agriculturally important animals. They have …

Pathway enrichment analysis helps researchers gain mechanistic insight into gene lists
generated from genome-scale (omics) experiments. This method identifies biological pathways …

The discovery of drivers of cancer has traditionally focused on protein-coding genes 1 , 2 , 3
– 4 . Here we present analyses of driver point mutations and structural variants in non-…

To the Editor: Pathway enrichment analysis is a common technique for interpreting gene
lists derived from high-throughput experiments1. Its success depends on the quality of gene …

The catalog of cancer driver mutations in protein-coding genes has greatly expanded in the
past decade. However, non-coding cancer driver mutations are less well-characterized and …

A comprehensive catalog of cancer driver mutations is essential for understanding tumorigenesis
and developing therapies. Exome-sequencing studies have mapped many protein-…

Parental infection can result in the production of offspring with enhanced immunity phenotypes.
Critically, the mechanisms underlying inherited immunity are poorly understood. Here, …

Medulloblastoma is the most common malignant brain tumor of childhood. Group 3
medulloblastoma, the most aggressive molecular subtype, frequently disseminates through the …

Discovery of cancer drivers has traditionally focused on the identification of protein-coding
genes. Here we present a comprehensive analysis of putative cancer driver mutations in both …