Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma
…, B Lu, MH Hsieh, L Bagdasarian… - Proceedings of the …, 2013 - National Acad Sciences
A growing number of agents targeting ligand-induced Wnt/β-catenin signaling are being
developed for cancer therapy. However, clinical development of these molecules is challenging …
developed for cancer therapy. However, clinical development of these molecules is challenging …
Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers
…, G McAllister, E Frias, L Bagdasarian… - Proceedings of the …, 2014 - National Acad Sciences
Defects in epigenetic regulation play a fundamental role in the development of cancer, and
epigenetic regulators have recently emerged as promising therapeutic candidates. We …
epigenetic regulators have recently emerged as promising therapeutic candidates. We …
Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/β-catenin signaling
…, A Loo, L Bagdasarian… - Proceedings of the …, 2011 - National Acad Sciences
Persistent expression of certain oncogenes is required for tumor maintenance. This phenotype
is referred to as oncogene addiction and has been clinically validated by anticancer …
is referred to as oncogene addiction and has been clinically validated by anticancer …
[HTML][HTML] Targeting HSF1 sensitizes cancer cells to HSP90 inhibition
Y Chen, J Chen, A Loo, S Jaeger, L Bagdasarian… - Oncotarget, 2013 - ncbi.nlm.nih.gov
The molecular chaperone heat shock protein 90 (HSP90) facilitates the appropriate folding
of various oncogenic proteins and is necessary for the survival of some cancer cells. HSP90 …
of various oncogenic proteins and is necessary for the survival of some cancer cells. HSP90 …
In-Depth Characterization and Validation in BRG1-Mutant Lung Cancers Define Novel Catalytic Inhibitors of SWI/SNF Chromatin Remodeling
…, R Ge, F Sigoillot, G Pardee, L Bagdasarian… - Biorxiv, 2019 - biorxiv.org
Members of the ATP-dependent SWI/SNF chromatin remodeling complexes are among the
most frequently mutated genes in cancer, suggesting their dysregulation plays a critical role. …
most frequently mutated genes in cancer, suggesting their dysregulation plays a critical role. …
Dual Wnt and EGFR-MAPK dependency of BRAFV600E-mutant colorectal cancer
Y Wang, M Palmer, S Jaeger, L Bagdasarian, S Qiu… - Cancer Research, 2015 - AACR
Aberrant Wnt pathway activation due to inactivating mutations in the gene encoding RNF43 (an
E3 ubiquitin ligase that promotes degradation of the Wnt receptors Frizzled and LRP6) …
E3 ubiquitin ligase that promotes degradation of the Wnt receptors Frizzled and LRP6) …
Abstract PR06: A functional screen of the epigenome identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers.
…, J Huber, A Lindeman, D Chen, L Bagdasarian… - Molecular Cancer …, 2013 - AACR
Epigenetic dysregulation is an emerging hallmark of cancers, and the identification of
recurrent somatic mutations in chromatin regulators implies a causal role for altered chromatin …
recurrent somatic mutations in chromatin regulators implies a causal role for altered chromatin …
A functional screen of the epigenome identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers
…, A Lindeman, D Chen, L Bagdasarian… - Molecular Cancer …, 2013 - oak.novartis.com
Epigenetic dysregulation is an emerging hallmark of cancers, and the identification of
recurrent somatic mutations in chromatin regulators implies a causal role for altered chromatin …
recurrent somatic mutations in chromatin regulators implies a causal role for altered chromatin …
Genes required for extracellular secretion of enterotoxin are clustered in Vibrio cholerae
LJ Overbye, M Sandkvist, M Bagdasarian - Gene, 1993 - Elsevier
Pleiotropic transposon insertion mutants of Vibrio cholerae that are unable to secrete enterotoxin,
HA/protease and chitinase through the outer membrane have been isolated. The gene…
HA/protease and chitinase through the outer membrane have been isolated. The gene…
General secretion pathway (eps) genes required for toxin secretion and outer membrane biogenesis in Vibrio cholerae
…, LP Hough, VM Morales, M Bagdasarian… - Journal of …, 1997 - Am Soc Microbiol
The general secretion pathway (GSP) of Vibrio cholerae is required for secretion of proteins
including chitinase, enterotoxin, and protease through the outer membrane. In this study, we …
including chitinase, enterotoxin, and protease through the outer membrane. In this study, we …