Identification of seven loci affecting mean telomere length and their association with disease
Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer
and several age-associated diseases. We report here a genome-wide meta-analysis of …
and several age-associated diseases. We report here a genome-wide meta-analysis of …
Rare and low-frequency coding variants alter human adult height
…, I Brandslund, G Breen, MH Brilliant, L Broer… - Nature, 2017 - nature.com
Height is a highly heritable, classic polygenic trait with approximately 700 common associated
variants identified through genome-wide association studies so far. Here, we report 83 …
variants identified through genome-wide association studies so far. Here, we report 83 …
[HTML][HTML] The transcriptional landscape of age in human peripheral blood
…, F Rivadeneira, J Van Rooij, L Stolk, L Broer… - Nature …, 2015 - nature.com
Disease incidences increase with age, but the molecular characteristics of ageing that lead
to increased disease susceptibility remain inadequately understood. Here we perform a …
to increased disease susceptibility remain inadequately understood. Here we perform a …
[HTML][HTML] Meta-analysis of telomere length in 19 713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect
Telomere length (TL) has been associated with aging and mortality, but individual differences
are also influenced by genetic factors, with previous studies reporting heritability estimates …
are also influenced by genetic factors, with previous studies reporting heritability estimates …
Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk
…, MK Bolla, JS Brand, H Brauch, H Brenner, L Broer… - Nature …, 2017 - nature.com
The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated
with various adult diseases. Using 1000 Genomes Project–imputed genotype data in up to …
with various adult diseases. Using 1000 Genomes Project–imputed genotype data in up to …
[HTML][HTML] Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria
Polycystic ovary syndrome (PCOS) is a disorder characterized by hyperandrogenism,
ovulatory dysfunction and polycystic ovarian morphology. Affected women frequently have …
ovulatory dysfunction and polycystic ovarian morphology. Affected women frequently have …
[PDF][PDF] The polygenic and monogenic basis of blood traits and diseases
Blood cells play essential roles in human health, underpinning physiological processes
such as immunity, oxygen transport, and clotting, which when perturbed cause a significant …
such as immunity, oxygen transport, and clotting, which when perturbed cause a significant …
Genetic insights into biological mechanisms governing human ovarian ageing
Reproductive longevity is essential for fertility and influences healthy ageing in women 1 , 2
, but insights into its underlying biological mechanisms and treatments to preserve it are …
, but insights into its underlying biological mechanisms and treatments to preserve it are …
[PDF][PDF] Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations
Most loci identified by GWASs have been found in populations of European ancestry (EUR).
In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including …
In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including …
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways
To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22
genome-wide association studies (GWAS) in 38,968 women of European descent, with …
genome-wide association studies (GWAS) in 38,968 women of European descent, with …