Notch signaling is known to regulate the proliferation and differentiation of intestinal stem and
progenitor cells; however, direct cellular targets and specific functions of Notch signals had …

Adenosine is a determinant of metabolic control of organ function increasing oxygen supply
through the A2 class of adenosine receptors and reducing oxygen demand through A1 …

The Notch-regulated transcription factor mouse atonal homolog 1 (Math1) is required for the
development of intestinal secretory cells, as demonstrated by the loss of goblet, endocrine …

Graft-versus-host disease (GVHD) is the main complication of allogeneic bone marrow
transplantation. Current strategies to control GVHD rely on global immunosuppression. These …

Background & Aims: Epithelial stem cells in the stomach are responsible for constant renewal
of the epithelium through generation of multiple gastric cell lineages that populate the …

To further understand the role of the peptide hormone gastrin in the development and function
of the stomach, we have generated gastrin-deficient mice by gene targeting in embryonic …

Pituitary thyrotropin (TSH) and gonadotropins (LH and FSH) are thought to be critical for
thyroid and gonadal development and function. Each of these pituitary hormones is a …

The gastrointestinal (GI) tract epithelium is continuously replenished by actively cycling stem
and progenitor cells. These cell compartments are regulated to balance proliferation and …

The Notch signaling pathway regulates intestinal epithelial cell homeostasis, including stem
cell maintenance, progenitor cell proliferation and differentiation. Notch1 and Notch2 …

Vitronectin (VN) is an abundant glycoprotein present in plasma and the extracellular matrix
of most tissues. Though the precise function of VN in vivo is unknown, it has been implicated …