Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism

S Pluchino, L Zanotti, B Rossi, E Brambilla, L Ottoboni… - Nature, 2005 - nature.com
In degenerative disorders of the central nervous system (CNS), transplantation of neural
multipotent (stem) precursor cells (NPCs) is aimed at replacing damaged neural cells 1 , 2 . …

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

…, X Jia, J Wang, PIW De Bakker, L Ottoboni… - Nature …, 2009 - nature.com
We report the results of a meta-analysis of genome-wide association scans for multiple
sclerosis (MS) susceptibility that includes 2,624 subjects with MS and 7,220 control subjects. …

A role for leukocyte-endothelial adhesion mechanisms in epilepsy

…, M Martinello, B Rossi, F Merigo, L Ottoboni… - Nature medicine, 2008 - nature.com
The mechanisms involved in the pathogenesis of epilepsy, a chronic neurological disorder
that affects approximately one percent of the world population, are not well understood 1 , 2 , …

[HTML][HTML] Therapeutic plasticity of neural stem cells

L Ottoboni, B von Wunster, G Martino - Frontiers in neurology, 2020 - frontiersin.org
Neural stem cells (NSCs) have garnered significant scientific and commercial interest in the
last 15 years. Given their plasticity, defined as the ability to develop into different phenotypes …

[HTML][HTML] Siponimod (BAF312) activates Nrf2 while hampering NFκB in human astrocytes, and protects from astrocyte-induced neurodegeneration

…, C Bassani, A De Angelis, F Ruffini, L Ottoboni… - Frontiers in …, 2020 - frontiersin.org
Multiple sclerosis (MS) is an inflammatory neurodegenerative disease of the central
nervous system (CNS) with heterogeneous pathophysiology. In its progressive course …

Phlebitis in amiodarone administration: incidence, contributing factors, and clinical implications

L Norton, LK Ottoboni, A Varady, CY Yang-Lu… - American Journal of …, 2013 - AACN
Background Intravenous amiodarone is an important treatment for arrhythmias, but peripheral
infusion is associated with direct irritation of vessel walls and phlebitis rates of 8% to 55%. …

An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity

L Ottoboni, BT Keenan, P Tamayo, M Kuchroo… - Science translational …, 2012 - science.org
The multiple sclerosis (MS) patient population is highly heterogeneous in terms of disease
course and treatment response. We used a transcriptional profile generated from peripheral …

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology

EM Bradshaw, LB Chibnik, BT Keenan, L Ottoboni… - Nature …, 2013 - nature.com
In our functional dissection of the CD33 Alzheimer's disease susceptibility locus, we found
that the rs3865444 C risk allele was associated with greater cell surface expression of CD33 …

The role of the CD58 locus in multiple sclerosis

…, LM Maier, AT Arthur, L Ottoboni… - Proceedings of the …, 2009 - National Acad Sciences
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system associated
with demyelination and axonal loss. A whole genome association scan suggested that …

CD8+ T cells from patients with acute multiple sclerosis display selective increase of adhesiveness in brain venules: a critical role for P-selectin glycoprotein ligand-1

…, B Rossi, S Bach, S Galgani, C Gasperini, L Ottoboni… - Blood, 2003 - ashpublications.org
Multiple sclerosis (MS) is considered an autoimmune inflammatory disease of the central
nervous system. Under physiologic conditions, we compared the adhesiveness of CD4 + and …