Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism
S Pluchino, L Zanotti, B Rossi, E Brambilla, L Ottoboni… - Nature, 2005 - nature.com
In degenerative disorders of the central nervous system (CNS), transplantation of neural
multipotent (stem) precursor cells (NPCs) is aimed at replacing damaged neural cells 1 , 2 . …
multipotent (stem) precursor cells (NPCs) is aimed at replacing damaged neural cells 1 , 2 . …
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
…, X Jia, J Wang, PIW De Bakker, L Ottoboni… - Nature …, 2009 - nature.com
We report the results of a meta-analysis of genome-wide association scans for multiple
sclerosis (MS) susceptibility that includes 2,624 subjects with MS and 7,220 control subjects. …
sclerosis (MS) susceptibility that includes 2,624 subjects with MS and 7,220 control subjects. …
A role for leukocyte-endothelial adhesion mechanisms in epilepsy
…, M Martinello, B Rossi, F Merigo, L Ottoboni… - Nature medicine, 2008 - nature.com
The mechanisms involved in the pathogenesis of epilepsy, a chronic neurological disorder
that affects approximately one percent of the world population, are not well understood 1 , 2 , …
that affects approximately one percent of the world population, are not well understood 1 , 2 , …
[HTML][HTML] Therapeutic plasticity of neural stem cells
L Ottoboni, B von Wunster, G Martino - Frontiers in neurology, 2020 - frontiersin.org
Neural stem cells (NSCs) have garnered significant scientific and commercial interest in the
last 15 years. Given their plasticity, defined as the ability to develop into different phenotypes …
last 15 years. Given their plasticity, defined as the ability to develop into different phenotypes …
[HTML][HTML] Siponimod (BAF312) activates Nrf2 while hampering NFκB in human astrocytes, and protects from astrocyte-induced neurodegeneration
…, C Bassani, A De Angelis, F Ruffini, L Ottoboni… - Frontiers in …, 2020 - frontiersin.org
Multiple sclerosis (MS) is an inflammatory neurodegenerative disease of the central
nervous system (CNS) with heterogeneous pathophysiology. In its progressive course …
nervous system (CNS) with heterogeneous pathophysiology. In its progressive course …
Phlebitis in amiodarone administration: incidence, contributing factors, and clinical implications
L Norton, LK Ottoboni, A Varady, CY Yang-Lu… - American Journal of …, 2013 - AACN
Background Intravenous amiodarone is an important treatment for arrhythmias, but peripheral
infusion is associated with direct irritation of vessel walls and phlebitis rates of 8% to 55%. …
infusion is associated with direct irritation of vessel walls and phlebitis rates of 8% to 55%. …
An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity
The multiple sclerosis (MS) patient population is highly heterogeneous in terms of disease
course and treatment response. We used a transcriptional profile generated from peripheral …
course and treatment response. We used a transcriptional profile generated from peripheral …
CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology
In our functional dissection of the CD33 Alzheimer's disease susceptibility locus, we found
that the rs3865444 C risk allele was associated with greater cell surface expression of CD33 …
that the rs3865444 C risk allele was associated with greater cell surface expression of CD33 …
The role of the CD58 locus in multiple sclerosis
…, LM Maier, AT Arthur, L Ottoboni… - Proceedings of the …, 2009 - National Acad Sciences
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system associated
with demyelination and axonal loss. A whole genome association scan suggested that …
with demyelination and axonal loss. A whole genome association scan suggested that …
CD8+ T cells from patients with acute multiple sclerosis display selective increase of adhesiveness in brain venules: a critical role for P-selectin glycoprotein ligand-1
…, B Rossi, S Bach, S Galgani, C Gasperini, L Ottoboni… - Blood, 2003 - ashpublications.org
Multiple sclerosis (MS) is considered an autoimmune inflammatory disease of the central
nervous system. Under physiologic conditions, we compared the adhesiveness of CD4 + and …
nervous system. Under physiologic conditions, we compared the adhesiveness of CD4 + and …