Genes and mechanisms involved in common complex diseases, such as the autoimmune
disorders that affect approximately 5% of the population, remain obscure. Here we identify …

The Wellcome Trust Case Control Consortium (WTCCC) primary genome-wide association (GWA)
scan 1 on seven diseases, including the multifactorial autoimmune disease type 1 …

The nonobese diabetic (NOD) mouse is a model of human autoimmune insulin dependent
diabetes mellitus. The NOD mouse also serves as a model for studying complex polygenic …

Genome-wide association studies are now identifying disease-associated chromosome
regions. However, even after convincing replication, the localization of the causal variant(s) …

Autoimmune diseases are thought to result from imbalances in normal immune physiology
and regulation. Here, we show that autoimmune disease susceptibility and resistance alleles …

… Address reprint requests to Linda S. Wicker, PhD, Merck, Sharp and Dohme Research
Laboratories, 80W-107, PO Box 2000, Rahway, NJ 07065. Received for publication 21 July 1985 …

Jak3 is a protein tyrosine kinase that is associated with the shared γ chain of receptors for
cytokines IL2, IL4, IL7, IL9, and IL13. We have discovered that a pyridone-containing tetracycle …

Diagnosis of the autoimmune disease type 1 diabetes (T1D) is preceded by the appearance
of circulating autoantibodies to pancreatic islets. However, almost nothing is known about …

Genome-wide association studies (GWAS) have identified over 300 regions associated with
more than 70 common diseases 1 . However, identifying causal genes within an associated …

As a result of genome-wide association studies in larger sample sets, there has been an
increase in identifying genes that influence susceptibility to individual immune-mediated …