Genome-wide association studies (GWAS) have laid the foundation for investigations into the
biology of complex traits, drug development and clinical guidelines. However, the majority …

The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated
with various adult diseases. Using 1000 Genomes Project–imputed genotype data in up to …

US Hispanic/Latino individuals are diverse in genetic ancestry, culture, and environmental
exposures. Here, we characterized and controlled for this diversity in genome-wide …

Background Spinal and bulbar muscular atrophy (SBMA) is caused by polyglutamine
expansion in the androgen receptor, which results in ligand-dependent toxicity. Animal models …

Although physical activity and sedentary behavior are moderately heritable, little is known
about the mechanisms that influence these traits. Combining data for up to 703,901 …

Objective: Several genome–wide association studies (GWAS) have demonstrated that
common genetic variants contribute to obesity. However, studies of this complex trait have …

The cohort design allows investigators to explore the genetic basis of a variety of diseases
and traits in a single study while avoiding major weaknesses of the case-control design. Most …

Several genome-wide studies have identified loci associated with reproductive traits, such
as ages of menarche and menopause, in women of European ancestry. In this study, we …

Obesity is of global health concern. There are well-described inverse relationships between
female pubertal timing and obesity. Recent genome-wide association studies of age at …

Although hundreds of genome-wide association studies-implicated loci have been reported
for adult obesity-related traits, less is known about the genetics specific for early-onset …