Microglia play critical roles in tissue homeostasis and can also modulate neuronal function
and synaptic connectivity. In contrast to astrocytes and oligodendrocytes, which arise from …

The mammalian CNS contains an abundant, widely distributed population of glial cells that
serve as oligodendrocyte progenitors. It has been reported that these NG2-immunoreactive …

Structural plasticity of dendritic spines and synapses is a fundamental mechanism governing
neuronal circuits and may form an enduring basis for information storage in the brain. We …

Oligodendrocyte precursor cells (OPCs) express NMDA receptors (NMDARs) and form
synapses with glutamatergic neurons throughout the CNS. Although glutamate influences the …

Astrocytes are ubiquitous CNS cells that support tissue homeostasis through ion buffering,
neurotransmitter recycling, and regulation of CNS vasculature. Yet, despite the essential …

Rationale: Sepsis-related mortality results in part from immunodeficiency secondary to
profound lymphoid apoptosis. The biological mechanisms responsible are not understood. …

Microglia are ubiquitous, macrophage like cells within the central nervous system (CNS)
that play critical roles in supporting neuronal health and viability. They can also influence …

A subset of midbrain dopamine (DA) neurons express vesicular glutamate transporter 2 (VgluT2),
which facilitates synaptic vesicle loading of glutamate. Recent studies indicate that …

One hallmark of normative brain aging is vast heterogeneity in whether older people succumb
to or resist cognitive decline. Resilience describes a brain’s capacity to maintain cognition …

During aging, microglia produce inflammatory factors, show reduced tissue surveillance,
altered interactions with synapses, and prolonged responses to CNS insults, positioning these …